Table 6: Average fold change for genes related to the inflammatory response in wild-type and PPARα-null male mice following a seven-day exposure to Wy-14,6431, PFOA1, or PFOS.

WTNull
SymbolGene nameEntrez no.Wy14,643 50 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kgPFOA 3 mg/kgPFOS 3 mg/kgPFOS 10 mg/kg

APCSamyloid P component,
serum
20219−1.50−2.33−1.23−1.28−1.191.411.13
C1QAcomplement component
1QA
12259−1.75−1.40−1.13−1.17−1.31−1.24−1.34**
C1Rcomplement component 1r50909−2.67−1.78−1.15−1.23*−1.221.16−1.17*
C1Scomplement component 1s317677−3.73−2.53−1.14−1.62**−1.521.06−1.11
C2complement component 212263−2.56−1.91−1.37−1.32*−1.181.101.11
C3complement component 312266−1.41−1.41−1.04−1.04−1.221.131.08*
C4Bcomplement component 4B12268−2.35−2.15−1.08−1.28−1.911.15−1.13
C4BPcomplement component
4 binding prot
12269−1.86−1.82−1.11−1.191.021.391.13
C6complement component 612274−2.66−1.27−1.35−1.081.901.121.06
C8Acomplement
component 8, alpha
230558−3.62−1.94−1.17−1.31*−1.171.191.04
C8Bcomplement
component 8, beta
110382−5.25−2.99−1.20−1.60**−1.121.111.02
C8Gcomplement
component 8, gamma
69379−1.59−1.35−1.05−1.17*−1.34−1.10−1.17**
C9complement
component 9
12279−2.12−2.64−1.35−1.58**−1.461.08−1.19*
CFBcomplement
factor B
14962−1.81−1.77−1.07−1.26−1.391.07−1.11
CFHcomplement
factor H
12628−2.39−2.30−1.19−1.62−1.761.45−1.35
CFIcomplement
factor I
12630−1.63−1.77−1.06−1.15−1.061.121.04
CRPC−reactive
protein
12944−1.33−1.39−1.01−1.15*1.321.141.13
CTSCcathepsin C13032−1.56−2.521.01−1.36−1.961.04−1.35
F10coagulation
factor X
14058−1.62−1.42−1.09−1.13−1.001.07−1.07
F11coagulation
factor XI
109821−2.17−2.68−1.41−2.08**−1.08−1.08−1.34*
F12coagulation
factor XII
58992−1.22−1.35−1.05−1.14−1.21−1.07−1.12*
F13Bcoagulation
factor XIII,
B polypeptide
14060−1.41−1.54−1.11−1.22**1.021.02−1.12
F2coagulation
factor II (thrombin)
14061−1.19−1.20−1.02−1.13*−1.101.02−1.02
F5coagulation
factor V
14067−1.78−1.53−1.09−1.44*−1.411.08−1.34*
F7coagulation
factor VII
14068−2.68−2.15−1.09−1.46**−1.231.03−1.03
F9coagulation
factor IX
14071−1.42−1.43−1.02−1.39*−1.331.07−1.19
FGAfibrinogen
alpha chain
14161−1.27−1.751.00−1.12−1.071.05−1.07
FGBfibrinogen
beta chain
110135−1.32−1.971.03−1.15−1.251.08−1.07
FGGfibrinogen gamma
chain
99571−1.14−1.681.02−1.15*−1.081.04−1.06
KLKB1kallikrein B,
plasma (Fletcher
factor) 1
16621−1.58−1.76−1.09−1.39*−1.05−1.03−1.18*
LUMlumican17022−1.34−1.271.02−1.20*−1.661.03−1.27
MASP1Mannan-
binding lectin1
17174−1.23−1.62−1.19−1.18*1.111.181.17*
MBL2Mannose-binding
lectin 2
17195−1.77−2.18−1.12−1.23*−1.36−1.20−1.28**
ORM2orosomucoid 218405−1.96−2.04−1.26−1.21−1.161.301.05
PROCprotein C19123−1.49−1.50−1.02−1.13*−1.09−1.01−1.09*
SAA1serum amyloid
A1
20209−3.71−3.98−2.751.04−2.766.512.55
SAA2serum amyloid
A2
20210−1.75−1.30−1.79−1.293.051.441.22
SAA4serum amyloid
A4, constitutive
20211−2.19−1.45−1.06−1.27−1.021.47−1.05
SERPINA1serpin peptidase
inhibitor, clade A1
20701−3.43−2.07−1.03−1.05**−1.161.11−1.33
SERPINC1serpin peptidase
inhibitor, clade C1
11905−1.19−1.21−1.03−1.08*−1.02−1.04−1.06*
SERPIND1serpin peptidase
inhibitor, clade D1
15160−1.62−1.70−1.08−1.25**−1.051.091.05
SERPINE1serpin peptidase
inhibitor, clade E1
187871.449.751.031.85**2.951.031.26*
SERPINF2serpin peptidase
inhibitor, clade F2
18816−1.15−1.871.01−1.13*1.021.121.05
SERPING1serpin peptidase
inhibitor, clade G1
12258−1.23−1.37−1.12−1.13−1.071.121.02
VWFvon Willebrand
factor
223711.061.12−1.251.07−1.511.221.14

1From Rosen et al. [1],
*Significantly different than control (P.03),
**Significantly different than control (P.0025).