Review Article
Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes
| Natural ligands | Ref. |
| lysophosphatidic acid | [349] | nitrolinoleic acid | [350] | 9-hydroxyoctadecadienoic acid | [351, 352] | 13-hydroxyoctadecadienoic acid | [351, 352] | 15-hydroxyeicosatetraenoic acid | [353] | prostaglandin D2 | [351, 353–357] | 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) | [351, 353–357] |
| Synthetic Ligands | Ref |
| Thiazolidinedione family (TZDs) | [18, 44, 313, 353, 354, 358, 359] | ciglitazone | | pioglitazone | | rosiglitazone | | troglitazone | | TZD 18 | | Nonsteroidal anti-inflammatory drugs | [353, 360, 361] | indomethacin | | ibuprofen | | flufenamic acid | | fenoprofen | | L-tyrosine-based | [351, 352] | GW-7845 | | GW-1929 | | diindolylmethane analogs | [351, 362] | triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) | [46, 351] | CDDO C-28 methyl ester derivative (CDDO-Me) | [214, 363, 364] | CDCO C-28 imidazole (CDDO-Im) | [50] | 1,1-bis[-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane (DIM #34), | [365] |
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