Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Figure 3

Induction of inflammatory mediators in whole EF assessed by gene expression at 6, 16, and 27-weeks. Data represented as HF/CH gene expression fold induction versus the Chow cohort for each time point. ($n=7\text{–}10$ mice for Chow and $n=10\text{–}15$ mice for the HF/CH group). The light gray bars indicate the 6-week timepoint, the dark gray bars indicate 16-week timepoint, and the black bars indicate the 27-week timepoint. Statistical significance was determined by a two tailed Welch t-test; *$P<.05$, **$P<.01$, and ***$P<.001$.

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