Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Figure 4

Pro-inflammatory ATMs express both pro- and anti-inflammatory mediators as assessed by gene expression. Four cell populations were sorted from the SVF from mice ($n\ge 3$) fed an HF/CH diet for approximately 16-weeks. The pro-inflammatory ATMs (PI-ATM: CD45+F480+CD11c+), resident ATMs (R-ATM: CD45+F480+CD11c−), a CD45+ unknown population (A: CD45+F480−CD11c+), and a CD45− unknown population (B: CD45 Thy1.2+Ly6C+/−CD11b−) were sorted and analyzed for gene expression from two independent sorts.

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