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PPAR Research
Volume 2011, Article ID 164925, 10 pages
http://dx.doi.org/10.1155/2011/164925
Research Article

Upregulation of Scavenger Receptor BI by Hepatic Nuclear Factor 4α through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism in Liver

Department of Physiology and Pathophysiology, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Beijing 100191, China

Received 10 August 2011; Accepted 20 September 2011

Academic Editor: Nanping Wang

Copyright © 2011 Yi Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. T. Odom, N. Zizlsperger, B. Gordon et al., “Control of pancreas and liver gene expression by HNF transcription factors,” Science, vol. 303, no. 5662, pp. 1378–1381, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Dhe-Paganon, K. Duda, M. Iwamoto, Y. I. Chi, and S. E. Shoelson, “Crystal structure of the HNF4α ligand binding domain in complex with endogenous fatty acid ligand,” Journal of Biological Chemistry, vol. 277, no. 41, pp. 37973–37976, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. G. B. Wisely, A. B. Miller, R. G. Davis et al., “Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids,” Structure, vol. 10, no. 9, pp. 1225–1234, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Yuan, T. C. Ta, M. Lin et al., “Identification of an endogenous ligand bound to a native orphan nuclear receptor,” Plos One, vol. 4, no. 5, Article ID e5609, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Yamagata, H. Furuta, N. Oda et al., “Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1),” Nature, vol. 384, no. 6608, pp. 458–460, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Groop, C. Pramfalk, E. Karlsson et al., “Control of ACAT2 liver expression by hnf4α: lesson from mody1 patients,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 8, pp. 1235–1241, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Barroso, J. Luan, E. Wheeler et al., “Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies,” Diabetes, vol. 57, no. 11, pp. 3161–3165, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. K. L. Mohlke and M. Boehnke, “The role of HNF4A variants in the risk of type 2 diabetes,” Current Diabetes Reports, vol. 5, no. 2, pp. 149–156, 2005. View at Google Scholar · View at Scopus
  9. W. S. Chen, K. Manova, D. C. Weinstein et al., “Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos,” Genes and Development, vol. 8, no. 20, pp. 2466–2477, 1994. View at Google Scholar · View at Scopus
  10. G. P. Hayhurst, Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez, “Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis,” Molecular and Cellular Biology, vol. 21, no. 4, pp. 1393–1403, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Xie, H. Liao, H. Dang et al., “Down-regulation of hepatic HNF4α gene expression during hyperinsulinemia via SREBPs,” Molecular Endocrinology, vol. 23, no. 4, pp. 434–443, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. P. O. Seglen, “Preparation of isolated rat liver cells,” Methods in Cell Biology, vol. 13, pp. 29–83, 1976. View at Google Scholar · View at Scopus
  13. K. E. Boyd and P. J. Farnham, “Myc versus USF: discrimination at the cad gene is determined by core promoter elements,” Molecular and Cellular Biology, vol. 17, no. 5, pp. 2529–2537, 1997. View at Google Scholar · View at Scopus
  14. K. Hirota, J. I. Sakamaki, J. Ishida et al., “A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding,” Journal of Biological Chemistry, vol. 283, no. 47, pp. 32432–32441, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Stroup and J. Y. Chiang, “HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1),” Journal of Lipid Research, vol. 41, no. 1, pp. 1–11, 2000. View at Google Scholar · View at Scopus
  16. A. Jonas, “Lecithin cholesterol acyltransferase,” Biochimica et Biophysica Acta, vol. 1529, no. 1–3, pp. 245–256, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. R. A. Ahmed, K. Murao, H. Imachi et al., “Human scavenger receptor class b type 1 is regulated by activators of peroxisome proliferators-activated receptor-γ in hepatocytes,” Endocrine, vol. 35, no. 2, pp. 233–242, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Malerod, M. Sporstol, L. K. Juvet, A. Mousavi, T. Gjoen, and T. Berg, “Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor γ and hepatocyte nuclear factor 4α,” Biochemical and Biophysical Research Communications, vol. 305, no. 3, pp. 557–565, 2003. View at Google Scholar
  19. R. K. Semple, V. K. Chatterjee, and S. O'Rahilly, “PPAR γ and human metabolic disease,” Journal of Clinical Investigation, vol. 116, no. 3, pp. 581–589, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Tontonoz and B. M. Spiegelman, “Fat and beyond: the diverse biology of PPARγ,” Annual Review of Biochemistry, vol. 77, pp. 289–312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Collino, M. Aragno, S. Castiglia et al., “Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation,” British Journal of Pharmacology, vol. 160, no. 8, pp. 1892–1902, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Medina-Gomez, S. Gray, and A. Vidal-Puig, “Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor γ (PPARγ) and PPARγcoactivator-1 (PGC1),” Public Health Nutrition, vol. 10, no. 10, pp. 1132–1137, 2007. View at Google Scholar
  23. A. Vidal-Puig, M. Jimenez-Linan, B. B. Lowell et al., “Regulation of PPAR γ gene expression by nutrition and obesity in rodents,” Journal of Clinical Investigation, vol. 97, no. 11, pp. 2553–2561, 1996. View at Google Scholar · View at Scopus
  24. C. P. Martinez-Jimenez, I. Kyrmizi, P. Cardot, F. J. Gonzalez, and I. Talianidis, “Hepatocyte nuclear factor 4α coordinates a transcription factor network regulating hepatic fatty acid metabolism,” Molecular and Cellular Biology, vol. 30, no. 3, pp. 565–577, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Chamouton, F. Hansmannel, J. A. Bonzo et al., “The peroxisomal 3-keto-acyl-CoA thiolase B gene expression is under the dual control of PPARa and HNF4a in the liver,” PPAR Research, vol. 2010, Article ID 352957, 17 pages, 2010. View at Publisher · View at Google Scholar
  26. S. Yu, K. Matsusue, P. Kashireddy et al., “Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression,” Journal of Biological Chemistry, vol. 278, no. 1, pp. 498–505, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Bedoucha, E. Atzpodien, and U. A. Boelsterli, “Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones,” Journal of Hepatology, vol. 35, no. 1, pp. 17–23, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Misawa, T. Horiba, N. Arimura et al., “Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes,” Journal of Biological Chemistry, vol. 278, no. 38, pp. 36176–36182, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. Q. Guo, S. P. Sahoo, P. R. Wang et al., “A novel peroxisome proliferator-activated receptor α/γ dual agonist demonstrates favorable effects on lipid homeostasis,” Endocrinology, vol. 145, no. 4, pp. 1640–1648, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Yin, H. Ma, X. Ge, P. A. Edwards, and Y. Zhang, “Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 2, pp. 328–336, 2011. View at Publisher · View at Google Scholar
  31. K. F. Kozarsky, M. H. Donahee, A. Rigotti, S. N. Iqbal, E. R. Edelman, and M. Krieger, “Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels,” Nature, vol. 387, no. 6631, pp. 414–417, 1997. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Yang, C. C. Chan, O. S. Kwon et al., “Regulation of peroxisome proliferator-activated receptor-γ in liver fibrosis,” American Journal of Physiology, vol. 291, no. 5, pp. G902–G911, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Y. Yue, C. Yin, J. L. Hou et al., “Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats,” Gut, vol. 59, no. 2, pp. 236–246, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. M. H. Black, T. E. Fingerlin, H. Allayee et al., “Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans,” Diabetes, vol. 57, no. 4, pp. 1048–1056, 2008. View at Publisher · View at Google Scholar · View at Scopus