Consequences of PPAR_α Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids

Table 5

Plasma concentrations of amino acid involved in cysteine metabolism in WT and PPARα-null (KO) mice fed diets containing either saturated FA (COCO diet) or ALA (LIN diet) for 8 weeks.

	WT		KO		𝑃 values
	COCO	LIN	COCO	LIN	ANOVA	Genotype; (G)	Diet; (D)	Interaction G∗D
Cysteine	16.3 ± 3.64	15.0 ± 2.12	17.2 ± 2.71	17.6 ± 3.87	0.9574	0.6144	0.8946	0.7949
Glycine	231 ± 17.3^a	219 ± 14.26^ab	170 ± 5.85^b	214 ± 16.3^ab	0.0236	0.0250	0.2603	0.0600
L-glutamic acid	23.6 ± 1.20	23.9 ± 3.09	21.5 ± 1.38	19.4 ± 1.20	0.3186	0.0800	0.6746	0.5300
Methionine	39.8 ± 1.89	38.9 ± 2.07	47.1 ± 3.83	49.8 ± 5.32	0.0980	0.0150	0.8094	0.6253
Taurine	436 ± 59.8	511 ± 38.0	389 ± 43.0	366 ± 22.4	0.1290	0.0403	0.5624	0.2797

Values are expressed in μM. Values are means ± standard errors for 7 mice per group. Mean values within a row sharing a same superscript letter, or without superscript letter, were not significantly different at 𝑃<0.05.