Research Article

Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats

Table 5

Mean values ± SD of bone architecture parameters in the femoral head, determined by means of μCT scanning analyses in sham controls, ovariectomized controls, and ovariectomized rats fed TTA for four months (Study II).

Femoral head CTR SHAM (sham-operated controls, 𝑁 = 1 0 ) CTR OVX (ovariectomized controls, 𝑁 = 1 0 ) TTA OVX (ovariectomized, given TTA, 𝑁 = 1 0 )

Cortical volume (Ct.V) (μm3) 3 1 . 9 8 ± 2 . 4 4 9 2 8 . 2 6 ± 1 . 4 9 1 aaa 2 9 . 2 3 ± 2 . 1 1 0 a
Cortical thickness (Ct.Th) (μm) 4 4 9 . 4 ± 1 8 . 8 0 4 2 2 . 3 ± 2 1 . 2 1 aa 4 2 2 . 9 ± 1 6 . 8 9 aa
Trabecular bone volume (BV) (μm3) 1 0 . 9 4 ± 1 . 3 6 5 1 0 . 6 9 ± 1 . 2 9 1 1 1 . 3 2 ± 1 . 4 6 5
Total volume (TV) (μm3) 2 0 . 1 2 ± 2 . 0 6 2 2 3 . 7 0 ± 2 . 9 2 6 aa 2 5 . 3 8 ± 2 . 9 2 0 aaa
Trabecular thickness (Tb.Th) (μm) 1 5 5 . 2 ± 6 . 8 9 3 1 4 7 . 2 ± 3 . 4 4 5 aa 1 4 9 . 9 ± 3 . 8 0 9
Connectivity density (CD) (1/mm3) 4 4 . 4 2 ± 9 . 1 6 0 4 6 . 3 4 ± 7 . 6 3 4 4 5 . 5 0 ± 7 . 6 9 8
Structure model index (SMI) (0.0–3.0) 0 . 6 5 0 9 ± 0 . 2 2 1 1 0 . 9 8 1 1 ± 0 . 1 3 9 1 aa 1 . 0 3 7 ± 0 . 2 2 9 4 aaa
Trabecular bone volume fraction (BV/TV) 0 . 5 4 3 6 ± 0 . 0 4 2 7 3 0 . 4 5 1 1 ± 0 . 0 2 4 2 1 aaa 0 . 4 4 8 0 ± 0 . 0 3 6 4 5 aaa

a, aa, aaa 𝑃 < 0 . 0 5 , 𝑃 < 0 . 0 1 , 𝑃 < 0 . 0 0 1 when compared to CTR SHAM group.