A Comparative Study of Mouse Hepatic and Intestinal Gene
Expression Profiles under PPARα Knockout by
Gene Set Enrichment Analysis
Figure 1
The number of identified up-or downregulated pathways in four studies of PPARα-dependent side. The bar chart showing the number of significantly identified pathways in our four studies of PPARα-dependent side according to the data of Additional File 1 which is available online at doi:10:1155/2011/629728.-axis represents the number of significantly identified pathways; -axis represents our four studies. The studies of Intestine-CT (KO/WT) and Liver-CT (KO/WT) are for identifying PPARα-dependent pathways; the studies of Intestine-WY (KO/WT) and Liver-WY (KO/WT) are for identifying WY14643 PPARα-dependent pathways, respectively, in mice small intestine and liver. Red color (up) is for upregulated pathways and blue color (down) is for downregulated pathways. There were 35 and 25 in study of Intestine-CT (KO/WT), the study in mouse small intestine of wild type versus PPARα-null mice treated with normal food in GSE5475; 80 and 62 in study of Intestine-WY (KO/WT), the study in mouse small intestine of wild type versus PPARα-null mice treated with PPARα agonist WY14643 for 5 days; 45 and 29 in study of Liver-CT (KO/WT), the study in mouse liver of wild type versus PPARα-null mice treated with normal food; and 62 and 74 in study of Liver-WY (KO/WT), the study in mouse liver of wild type versus PPARα-null mice treated with the PPARα agonist WY14643 for 5 days, respectively, for up-and down-regulated pathways.
