A Comparative Study of Mouse Hepatic and Intestinal Gene
Expression Profiles under PPARα Knockout by
Gene Set Enrichment Analysis
Comparison of PPARα-dependent regulated pathways between in small intestine and liver of mice. Venn diagram showing the overlapping significantly identified pathways by the comparison of PPARα-dependent regulated pathways between in small intestine and liver of mice. The studies of Intestine-CT (KO/WT) and Liver-CT (KO/WT) are for identifying PPARα-dependent pathways; the studies of Intestine-WY (KO/WT) and Liver-WY (KO/WT) are for identifying WY14643 PPARα-dependent pathways, respectively, in mice small intestine and liver. Pathways of -value less than 0.01 were considered to be significantly regulated. Red color is for upregulated pathways and green color is for downregulated pathways. In Figure 2(a), there were 16 upregulated and 9 downregulated PPARα-dependent pathways in common; in Figure 2(b), there were 31 upregulated and 39 downregulated WY14643 PPARα-dependent pathways in common in both tissues of mice.