PPAR Research / 2011 / Article / Fig 3

Research Article

A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis

Figure 3

The number of identified up-or downregulated pathways in other four studies of PPARα-independent side or WY14643-dependent side. The bar chart showing the number of significantly identified pathways ( 𝑃 0 . 0 1 ) in additional four studies of PPARα-independent side or WY14643-dependent side according to the data of Additional File 1. 𝑋 -axis represents the number of significantly identified pathways; 𝑌 -axis represents our four studies. The studies of Intestine-WT (CT/WY) and Liver-WT (CT/WY) are for identifying WY14643-dependent pathways; the studies of Intestine-KO (CT/WY) and Liver-KO (CT/WY) are for identifying PPARα-independent pathways, respectively, in mice small intestine and liver. Red color (up) is for upregulated pathways and blue color (down) is for downregulated pathways. There were 86 and 50 in study of Intestine-WT (CT/WY), the study in mouse wild type intestine of comparison between with normal food and with the treatment of WY14643 in GSE5475; 46 and 37 in study of Intestine-KO (CT/WY), the study in mouse PPARα-null intestine of the comparison between with normal food and with the treatment of WY14643 also in GSE5475; 52 and 68 in study of Liver-WT (CT/WY), the study in mouse wild type liver of comparison between with normal food and with the treatment of WY14643 in GSE8295; And 9 and 15 in study of Liver-KO (CT/WY), the study in mouse PPARα-null liver of the comparison between with normal food and with the treatment of WY14643 also in GSE8295, respectively, for up-and downregulated pathways.
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