PPAR Research / 2011 / Article / Tab 3

Research Article

A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis

Table 3

The highly common down and up regulated pathways identified in studies of PPARα-dependent or independent effects both in liver and small intestine tissues of mice.

PathwaysPPARα-dependent (KO/WT)PPARα-independent (CT/WY)

Upregulated00511: other glycan degradation05322: systemic lupus erythematosus
04142: lysosome
04144: endocytosis
04540: gap junction

Downregulated00071: fatty acid metabolism00010: glycolysis/Gluconeogenesis
00380: tryptophan metabolism00071: fatty acid metabolism
00620: pyruvate metabolism00640: propanoate metabolism
00770: pantothenate and CoA biosynthesis  
01040: biosynthesis of unsaturated fatty acids  
03320: PPAR signaling pathway
00410: beta-Alanine metabolism
00561: glycerolipid metabolism

There were 12 highly common pathways in comparisons of PPARα-dependent studies, including 4 upregulated and 8 downregulated pathways in both liver and small intestine of mice. The PPARα-dependent comparisons were made between PPARα null and wild type mice; By contrast, there were only 4 highly common pathways in comparisons of PPARα-independent studies, including 1 upregulated and 3 downregulated pathways in both liver and small intestine of mice. The comparisons were made between with normal food and with WY14643 treatment.