A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARα Knockout by Gene Set Enrichment Analysis

Table 3

The highly common down and up regulated pathways identified in studies of PPARα-dependent or independent effects both in liver and small intestine tissues of mice.

Pathways	PPARα-dependent (KO/WT)	PPARα-independent (CT/WY)
Upregulated	00511: other glycan degradation	05322: systemic lupus erythematosus
	04142: lysosome
	04144: endocytosis
	04540: gap junction
Downregulated	00071: fatty acid metabolism	00010: glycolysis/Gluconeogenesis
	00380: tryptophan metabolism	00071: fatty acid metabolism
	00620: pyruvate metabolism	00640: propanoate metabolism
	00770: pantothenate and CoA biosynthesis
	01040: biosynthesis of unsaturated fatty acids
	03320: PPAR signaling pathway
	00410: beta-Alanine metabolism
	00561: glycerolipid metabolism

There were 12 highly common pathways in comparisons of PPARα-dependent studies, including 4 upregulated and 8 downregulated pathways in both liver and small intestine of mice. The PPARα-dependent comparisons were made between PPARα null and wild type mice; By contrast, there were only 4 highly common pathways in comparisons of PPARα-independent studies, including 1 upregulated and 3 downregulated pathways in both liver and small intestine of mice. The comparisons were made between with normal food and with WY14643 treatment.