Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor 𝜸 Agonist In Vivo

Figure 2

Influence of RXR antagonists on PPARγ agonist-induced anti-inflammatory effects. Pioglitazone was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. RXR antagonist, NS-4TF was injected into subplantar 15 min before carrageenan injection at doses of 10 and 30 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (𝑛=7). **: Significantly different from the control group at 𝑃<0.01 (Dunnett’s test). ^†: Significantly different from the vehicle group at 𝑃<0.05 (Dunnett’s test).