Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor Agonist In Vivo
Figure 3
Involvement of RXR on carrageenan-induced paw edema in mice. (a) Dose dependence and time course of RXR agonist, NEt-3IP on carrageenan-induced paw edema in mice. NEt-3IP was orally administrated 3 h before carrageenan injection at doses of 1, 3, and 10 mg/kg. The control group was received 0.5% carboxymethylcellulose. (b) Effect of RXR antagonist, NS-4TF on NEt-3IP induced anti-inflammatory effect. NEt-3IP was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. NS-4TF was injected 15 min before carrageenan injection at doses of 10 and 30 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (). *,**: Significantly different from the control group at and , respectively, (Dunnett’s test). ††: Significantly different from the vehicle group at (Dunnett’s test).
