Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor 𝜸 Agonist In Vivo

Figure 4

Influence of PPAR antagonists on RXR agonist and PPARγ agonist-induced anti-inflammatory effects. NEt-3IP was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. Nonselective PPAR antagonist, BADGE was injected intraperitoneal 30 min before carrageenan injection at doses of 10 and 30 mg/kg. PPARα antagonist, GW6471 was injected into subplantar 15 min before carrageenan injection at doses of 10 and 30 μg/paw. PPARγ antagonist, GW9662 was injected into subplantar 15 min before carrageenan injection at doses of 3 and 10 μg/paw. PPARδ antagonist, JKPL-85 was injected into subplantar 15 min before carrageenan injection at doses of 10 and 30 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (𝑛=7). **: Significantly different from the control group at 𝑃<0.01 (Dunnett’s test). ^†,^††: Significantly different from the vehicle group at 𝑃<0.05 and 𝑃<0.01, respectively (Dunnett’s test).