Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor 𝜸 Agonist In Vivo

Figure 6

Influence of RNA polymerase inhibitor on PPARγ agonist and RXR agonist-induced anti-inflammatory effects. (a) Effect of RNA polymerase inhibitor, actinomycin D on pioglitazone-induced anti-inflammatory effect. Pioglitazone was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. Actinomycin D was injected 15 min before carrageenan injection at doses of 3 and 10 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. (b) Effect of actinomycin D on NEt-3IP-induced anti-inflammatory effect. NEt-3IP was orally administrated 3 h before carrageenan injection at a dose of 10 mg/kg. Actinomycin D was injected 15 min before carrageenan injection at doses of 3 and 10 μg/paw. The vehicle group received physiological saline including 10% dimethylsulphoxide. Each column and vertical bar represents the means ± S.E.M. (𝑛=7). **: Significantly different from the control group at 𝑃<0.01 (Dunnett’s test). ^†,^††: Significantly different from the vehicle group at 𝑃<0.05 and 𝑃<0.01, respectively, (Dunnett’s test).

(a)

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