PPAR Research / 2012 / Article / Fig 1

Review Article

Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity

Figure 1

Obesity-induced liver oxidative stress (A), hypoadiponectinemia (B), and endoplasmic reticulum stress (C) as factors leading to hepatic steatosis in nonalcoholic fatty liver disease. Abbreviations: 5(6)D: delta-5(6) desaturase; FA, fatty acid; LCPUFA: long-chain polyunsaturated fatty acid; PPAR-α(γ): peroxisome proliferator-activated receptor-α(γ); SREBP-1c: sterol regulatory element binding protein-1c; UPR: unfolded protein response.