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PPAR Research
Volume 2012, Article ID 145654, 10 pages
http://dx.doi.org/10.1155/2012/145654
Research Article

Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China

Received 14 February 2012; Revised 25 April 2012; Accepted 25 April 2012

Academic Editor: Brian Finck

Copyright © 2012 Zhou Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. S. Ohashi, “T-cell signalling and autoimmunity: molecular mechanisms of disease,” Nature Reviews Immunology, vol. 2, no. 6, pp. 427–438, 2002. View at Google Scholar
  2. S. Taleb, A. Tedgui, and Z. Mallat, “Interleukin-17: friend or foe in atherosclerosis?” Current Opinion in Lipidology, vol. 21, no. 5, pp. 404–408, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. B. M. Segal, “Th17 cells in autoimmune demyelinating disease,” Seminars in Immunopathology, vol. 32, no. 1, pp. 71–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Brand, “Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease,” Gut, vol. 58, no. 8, pp. 1152–1167, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. A. B. Pernis, “Th17 cells in rheumatoid arthritis and systemic lupus erythematosus,” Journal of Internal Medicine, vol. 265, no. 6, pp. 644–652, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Emamaullee, J. Davis, S. Merani et al., “Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice,” Diabetes, vol. 58, no. 6, pp. 1302–1311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. L. Dart, E. Jankowska-Gan, G. Huang et al., “Interleukin-17-dependent autoimmunity to collagen type v in atherosclerosis,” Circulation Research, vol. 107, no. 9, pp. 1106–1116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Smith, K. M. R. Prasad, M. Butcher et al., “Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice,” Circulation, vol. 121, no. 15, pp. 1746–1755, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. Q. Gao, Y. Jiang, T. Ma et al., “A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice,” Journal of Immunology, vol. 185, no. 10, pp. 5820–5827, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. G. K. Hansson, “Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease,” The New England Journal of Medicine, vol. 352, no. 16, pp. 1685–1626, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Taleb, M. Romain, B. Ramkhelawon et al., “Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis,” Journal of Experimental Medicine, vol. 206, no. 10, pp. 2067–2077, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Zhang, X. Zeng, J. Guo, and X. Wang, “Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes,” Cardiovascular Research, vol. 53, no. 4, pp. 1035–1042, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Feng, Z. Zhang, W. Kong, B. Liu, Q. Xu, and X. Wang, “Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/-mice,” Cardiovascular Research, vol. 84, no. 1, pp. 155–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Ahmed, O. Ziouzenkova, J. Brown et al., “PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?” Journal of Internal Medicine, vol. 262, no. 2, pp. 184–198, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Zambon, P. Gervois, P. Pauletto, J. C. Fruchart, and B. Staels, “Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-α activators: clinical and experimental evidence,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 5, pp. 977–986, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Israelian-Konaraki and P. D. Reaven, “Peroxisome proliferator-activated receptor-alpha and atherosclerosis: from basic mechanisms to clinical implications,” Cardiology in Review, vol. 13, no. 5, pp. 240–246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. J. D. Brown and J. Plutzky, “Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets,” Circulation, vol. 115, no. 4, pp. 518–533, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. S. H. Han, M. J. Quon, and K. K. Koh, “Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-α activators,” Hypertension, vol. 46, no. 5, pp. 1086–1092, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. A. E. Lovett-Racke, R. Z. Hussain, S. Northrop et al., “Peroxisome proliferator-activated receptor α agonists as therapy for autoimmune disease,” Journal of Immunology, vol. 172, no. 9, pp. 5790–5798, 2004. View at Google Scholar · View at Scopus
  20. J. W. Lee, P. J. Bajwa, M. J. Carson et al., “Fenofibrate represses interleukin-17 and interferon-γ expression and improves colitis in interleukin-10-deficient mice,” Gastroenterology, vol. 133, no. 1, pp. 108–123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Marx, B. Kehrle, K. Kohlhammer et al., “PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis,” Circulation Research, vol. 90, no. 6, pp. 703–710, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Chen, A. Laurence, and J. J. O'Shea, “Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation,” Seminars in Immunology, vol. 19, no. 6, pp. 400–408, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. I. I. Ivanov, L. Zhou, and D. R. Littman, “Transcriptional regulation of Th17 cell differentiation,” Seminars in Immunology, vol. 19, no. 6, pp. 409–417, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Zhou, J. E. Lopes, M. M. W. Chong et al., “TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function,” Nature, vol. 453, no. 7192, pp. 236–240, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Wang, J. Zheng, X. Bai et al., “ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries,” Circulation Research, vol. 104, no. 5, pp. 688–698, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Dai, W. Li, L. Chang et al., “Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis,” Free Radical Biology and Medicine, vol. 41, no. 10, pp. 1566–1577, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. L. E. Harrington, R. D. Hatton, P. R. Mangan et al., “Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages,” Nature Immunology, vol. 6, no. 11, pp. 1123–1132, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Park, Z. Li, X. O. Yang et al., “A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17,” Nature Immunology, vol. 6, no. 11, pp. 1133–1141, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. T. A. S. Duhaney, L. Cui, M. K. Rude et al., “Peroxisome proliferator-activated receptor α-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload,” Hypertension, vol. 49, no. 5, pp. 1084–1094, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Yamashita, “Peroxisome proliferator-activated receptor α-independent effects of peroxisome proliferators on cysteinyl leukotriene production in mast cells,” European Journal of Pharmacology, vol. 556, no. 1–3, pp. 172–180, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Kim, J. H. Ahn, J. H. Kim et al., “Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway,” Experimental Eye Research, vol. 84, no. 5, pp. 886–893, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. D. Chanda, C. H. Lee, Y. H. Kim et al., “Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner,” Hepatology, vol. 50, no. 3, pp. 880–892, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Joe, M. H. Do, E. Seo et al., “Fenofibrate antagonizes Chk2 activation by inducing Wip1 expression: implications for cell proliferation and tumorigenesis,” Life Sciences, vol. 86, no. 19-20, pp. 716–721, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Mucida, Y. Park, G. Kim et al., “Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid,” Science, vol. 317, no. 5835, pp. 256–260, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Veldhoen, K. Hirota, A. M. Westendorf et al., “The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins,” Nature, vol. 453, no. 7191, pp. 106–109, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Cui, X. Qin, L. Wu et al., “Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation,” Journal of Clinical Investigation, vol. 121, no. 2, pp. 658–670, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Kanakasabai, W. Chearwae, C. C. Walline, W. Iams, S. M. Adams, and J. J. Bright, “Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis,” Immunology, vol. 130, no. 4, pp. 572–588, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Klotz, S. Burgdorf, I. Dani et al., “The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity,” Journal of Experimental Medicine, vol. 206, no. 10, pp. 2079–2089, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. X. O. Yang, A. D. Panopoulos, R. Nurieva et al., “STAT3 regulates cytokine-mediated generation of inflammatory helper T cells,” Journal of Biological Chemistry, vol. 282, no. 13, pp. 9358–9363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. Z. Chen, A. Laurence, Y. Kanno et al., “Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 21, pp. 8137–8142, 2006. View at Publisher · View at Google Scholar
  41. E. Beurel, W. I. Yeh, S. M. Michalek, L. E. Harrington, and R. S. Jope, “Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells,” Journal of Immunology, vol. 186, no. 3, pp. 1391–1398, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. N. R. Locke, S. J. Patterson, M. J. Hamilton, L. M. Sly, G. Krystal, and M. K. Levings, “SHIP regulates the reciprocal development of T regulatory and Th17 cells,” Journal of Immunology, vol. 183, no. 2, pp. 975–983, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Xiao, H. Jin, T. Korn et al., “Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression,” Journal of Immunology, vol. 181, no. 4, pp. 2277–2284, 2008. View at Google Scholar · View at Scopus
  44. C. Chen, X. Liu, B. Wan, and J. Z. Zhang, “Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation,” Journal of Immunology, vol. 183, no. 1, pp. 246–253, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Monari, S. Bevilacqua, M. Piccioni et al., “A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production,” Journal of Immunology, vol. 183, no. 1, pp. 191–200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. P. Gervois, R. Kleemann, A. Pilon et al., “Global suppression of IL-6-induced acute phase response gene expression after chronic in Vivo treatment with the peroxisome proliferator-activated receptor-α activator fenofibrate,” Journal of Biological Chemistry, vol. 279, no. 16, pp. 16154–16160, 2004. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Y. Park, Y. R. Cho, B. N. Finck et al., “Cardiac-specific overexpression of peroxisome proliferator-activated receptor-α causes insulin resistance in heart and liver,” Diabetes, vol. 54, no. 9, pp. 2514–2524, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. C. Dong, “TH17 cells in development: an updated view of their molecular identity and genetic programming,” Nature Reviews Immunology, vol. 8, no. 5, pp. 337–348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  49. Z. Zhou, Y. Liang, Y. Gao, W. Kong, J. Feng, and X. Wang, “Fenofibrate enhances the in vitro differentiation of Foxp3+ regulatory T cells in mice,” PPAR Research, vol. 2012, Article ID 529035, 10 pages, 2012. View at Publisher · View at Google Scholar
  50. J. M. Damsker, A. M. Hansen, and R. R. Caspi, “Th1 and Th17 cells: adversaries and collaborators,” Annals of the New York Academy of Sciences, vol. 1183, pp. 211–221, 2010. View at Publisher · View at Google Scholar · View at Scopus