Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">α</mml:mi></mml:math> Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver

<table>mRNA expressions of hepatic PPAR<i>α</i> and its related genes in duplicate analyses. Expressions of mRNA were analyzed by quantitative real-time PCR. Each mRNA was normalized to the level of GAPDH-mRNA expression in the same preparation, and mean of control in <i>mPPAR<i>α</i></i> mice was assigned a value of 1.0. White, gray, and black columns represent control values, 2.5 mM- and 5.0 mM-treated group, respectively. Each column and bar represents mean ± S.D., respectively. A logarithmic transformation was applied to MTP-mRNA before statistical analysis. *Significantly different from respective controls (<svg height="11.375" id="M75" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x35"></use></g>
</svg>). <sup>#</sup>Significantly different among genotypes (<svg height="11.375" id="M76" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x35"></use></g>
</svg>).</table>

PPAR Research

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Figure 2

Figure 2: Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">α</mml:mi></mml:math> Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver 

Figure 2 | Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver 