Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury
Figure 2
Effect of rosiglitazone (RGZ) on morphological alterations in the kidney of Sprague-Dawley rats in renal I/R injury. Renal cryostat sections were stained with periodic acid-Schiff (PAS). Injury was graded by a score as described in Section 2. (a) Total injury score (mean values from Figure 2(b) were taken together). n as indicated. #, *Statistically significant difference as indicated. (b) Single criteria of histopathologic investigations are shown. n from 4 to 6 for each group. *Statistically significant difference () between clamp versus clamp + RGZ; $statistically significant difference () between control, sham, sham + RGZ versus clamp and clamp+RGZ; statistically significant difference () between control, sham, sham + RGZ versus clamp alone. (c) Representative sections of images of the renal cortex after PAS staining are shown. Control group, clamp group, and clamp + RGZ group as indicated on the sections. Some of the lesion criteria are exemplified. Arrowhead points to loss of the brush border. Arrow shows vacuolization in epithelial cells of the tubuli. Lines without arrowheads show tubular epithelial cells with defragmented nuclei.
