The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils
Figure 1
The effect on eotaxin-induced eosinophil migration of agonists to PPARγ ((a) rosiglitazone), PPARα ((b) GW9578), and PPARδ ((c) GW50516) at low (0.1–100 nM; 9 subjects) and high concentrations (1000–100,000 nM; 6 subjects). Representative pictures at 200x magnification of the leading edge of the nitrocellulose filter after incubation with eotaxin (d) and eotaxin with 100 μM rosiglitazone (e). Data are shown as mean SEM and expressed as % of the response to eotaxin.
