Research Article

AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

Figure 3

Induction of apoptosis. Induction of apoptosis in CaCo-2 cells treated with 5 μM clofibrate, 0.1 μM AS601245, and the association of these two compounds (Clofi + AS601245). Apoptosis was evaluated at 0, 24, and 48 hours after the treatments, by measuring caspase 3/7 activity. 20 mM butyrate was used as a positive control. Results normalized to the respective control value for each experimental time is the mean ± SD of three separate experiments from three different preparations for each condition. Variance analysis: ** versus control.
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