Figure 1: Response to PPARα agonists in aortas and MCAs of WT mice. Concentration-response curves to three different PPARα agonists (gemfibrozil, WY14643, and GW7647) in (a) mouse aortic rings precontracted with 10−5 M PGF2α by using isometric tension myography and (b) MCAs preconstricted with 10−5 M PE by using isobaric myography. All three PPARα agonists relaxed aortic rings ( 𝑛 = 3–5) as well as dilated the MCA ( 𝑛 = 7 ). Data are means ± SEM. *Indicates P ≤ 0.05.