PPAR𝜶-Independent Arterial Smooth Muscle Relaxant Effects of PPAR𝜶 Agonists

Figure 2

Nonreceptor-mediated responses to PPARα agonists. Concentration responses to GW7647 and WY14643 in aortic rings (a) and (b) and in MCAs (c) and (d) isolated from WT and Ppar𝛼^−/− mice (𝑛=3–5). Responses to GW7647 and WY14643 in aortic rings and MCAs of Ppar𝛼^−/− mice were identical to that of WT (control) mice indicating a receptor-independent effect. Data are means ± SEM. *Indicates P ≤ 0.05.

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