302495.fig.002a
(a)
302495.fig.002b
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302495.fig.002c
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302495.fig.002d
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Figure 2: Nonreceptor-mediated responses to PPARα agonists. Concentration responses to GW7647 and WY14643 in aortic rings (a) and (b) and in MCAs (c) and (d) isolated from WT and P p a r 𝛼 − / − mice ( 𝑛 = 3 –5). Responses to GW7647 and WY14643 in aortic rings and MCAs of P p a r 𝛼 − / − mice were identical to that of WT (control) mice indicating a receptor-independent effect. Data are means ± SEM. *Indicates P ≤ 0.05.