Transcriptional Activity of PGC-1<svg style="vertical-align:-0.216pt;width:14.1125px;" id="M1" height="10.725" version="1.1" viewBox="0 0 14.1125 10.725" width="14.1125"      xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,0,0,-.022,.062,10.4)"><path id="x1D736" d="M505 450h125l-163 -259q-1 -4 -1 -12q0 -19 1 -23q9 -98 41 -98q36 0 58 76l24 -7q-34 -139 -121 -139q-32 0 -57.5 24t-31.5 55q-72 -77 -181 -77q-73 0 -114 44t-41 124q0 118 79 210q79 93 197 93q51 0 86 -27t50 -71zM369 281q0 141 -62 141q-43 0 -95 -84
q-52 -82 -52 -195q0 -50 15 -83t42 -33q35 0 79 57q43 58 67 121q6 35 6 76z"/></g>

		
	
</svg> and NT-PGC-1<svg style="vertical-align:-0.216pt;width:14.1125px;" id="M2" height="10.725" version="1.1" viewBox="0 0 14.1125 10.725" width="14.1125"      xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,0,0,-.022,.062,10.4)"><use xlink:href="#x1D736"/></g>

		
	
</svg> Is Differentially Regulated by Twist-1 in Brown Fat Metabolism

<table>Interactions of Twist-1 with PGC-1<i>α</i> but not with NT-PGC-1<i>α</i>. PGC-1<i>α</i>-HA (a) and NT-PGC-1<i>α</i>-HA (b) were co-expressed with Flag-Twist-1 in COS-1 cells. Immunoprecipitates with IgG or anti-Flag antibody were separated by SDS-PAGE and immunoblotted with anti- PGC-1<i>α</i> (a, top panel) or HA antibody (b, top panel). Expression of Flag-Twist-1 was confirmed by probing with anti-Flag antibody (a and b, bottom panels).</table>

PPAR Research

fig2

Figure 2

Figure 2: Transcriptional Activity of PGC-1<svg style="vertical-align:-0.216pt;width:14.1125px;" id="M1" height="10.725" version="1.1" viewBox="0 0 14.1125 10.725" width="14.1125"      xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,0,0,-.022,.062,10.4)"><path id="x1D736" d="M505 450h125l-163 -259q-1 -4 -1 -12q0 -19 1 -23q9 -98 41 -98q36 0 58 76l24 -7q-34 -139 -121 -139q-32 0 -57.5 24t-31.5 55q-72 -77 -181 -77q-73 0 -114 44t-41 124q0 118 79 210q79 93 197 93q51 0 86 -27t50 -71zM369 281q0 141 -62 141q-43 0 -95 -84
q-52 -82 -52 -195q0 -50 15 -83t42 -33q35 0 79 57q43 58 67 121q6 35 6 76z"/></g>

		
	
</svg> and NT-PGC-1<svg style="vertical-align:-0.216pt;width:14.1125px;" id="M2" height="10.725" version="1.1" viewBox="0 0 14.1125 10.725" width="14.1125"      xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg">
	
		
			<g transform="matrix(.022,0,0,-.022,.062,10.4)"><use xlink:href="#x1D736"/></g>

		
	
</svg> Is Differentially Regulated by Twist-1 in Brown Fat Metabolism 

Figure 2 | Transcriptional Activity of PGC-1
	
		
			

		
	
 and NT-PGC-1
	
		
			

		
	
 Is Differentially Regulated by Twist-1 in Brown Fat Metabolism 

PPAR Research

Transcriptional Activity of PGC-1 and NT-PGC-1 Is Differentially Regulated by Twist-1 in Brown Fat Metabolism

Figure 2