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PPAR Research
Volume 2012 (2012), Article ID 320454, 7 pages
http://dx.doi.org/10.1155/2012/320454
Research Article

Transcriptional Activity of PGC-1 and NT-PGC-1 Is Differentially Regulated by Twist-1 in Brown Fat Metabolism

Laboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA

Received 8 August 2012; Revised 5 September 2012; Accepted 7 September 2012

Academic Editor: Shihori Tanabe

Copyright © 2012 Hee-Jin Jun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Puigserver, Z. Wu, C. W. Park, R. Graves, M. Wright, and B. M. Spiegelman, “A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis,” Cell, vol. 92, no. 6, pp. 829–839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. Wu, P. Puigserver, U. Andersson et al., “Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1,” Cell, vol. 98, no. 1, pp. 115–124, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. J. C. Yoon, P. Puigserver, G. Chen et al., “Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1,” Nature, vol. 413, no. 6852, pp. 131–138, 2001. View at Publisher · View at Google Scholar
  4. J. Rhee, Y. Inoue, J. C. Yoon et al., “Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, pp. 4012–4017, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Lin, H. Wu, P. T. Tarr et al., “Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres,” Nature, vol. 418, no. 6899, pp. 797–801, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. R. B. Vega, J. M. Huss, and D. P. Kelly, “The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes,” Molecular and Cellular Biology, vol. 20, no. 5, pp. 1868–1876, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. J. St-Pierre, S. Drori, M. Uldry et al., “Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators,” Cell, vol. 127, no. 2, pp. 397–408, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Puigserver, J. Rhee, J. Lin et al., “Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1,” Molecular Cell, vol. 8, no. 5, pp. 971–982, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Knutti, D. Kressler, and A. Kralli, “Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 17, pp. 9713–9718, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Jäer, C. Handschin, J. St-Pierre, and B. M. Spiegelman, “AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 29, pp. 12017–12022, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Teyssier, H. Ma, R. Emter, A. Kralli, and M. R. Stallcup, “Activation of nuclear receptor coactivator PGC-1α by arginine methylation,” Genes and Development, vol. 19, no. 12, pp. 1466–1473, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Li, B. Monks, Q. Ge, and M. J. Birnbaum, “Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator,” Nature, vol. 447, no. 7147, pp. 1012–1016, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. J. T. Rodgers, C. Lerin, W. Haas, S. P. Gygi, B. M. Spiegelman, and P. Puigserver, “Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1,” Nature, vol. 434, no. 7029, pp. 113–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Herzig, F. Long, U. S. Jhala et al., “CREB regulates hepatic gluconeogenesis through the coactivator PGC-1,” Nature, vol. 413, no. 6852, pp. 179–183, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Zhang, P. Huypens, A. W. Adamson et al., “Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1α,” The Journal of Biological Chemistry, vol. 284, no. 47, pp. 32813–32826, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. J. S. Chang, P. Huypens, Y. Zhang, C. Black, A. Kralli, and T. W. Gettys, “Regulation of NT-PGC-1αsubcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1,” The Journal of Biological Chemistry, vol. 285, no. 23, pp. 18039–18050, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. S. Chang, V. Fernand, Y. Zhang et al., “NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis,” The Journal of Biological Chemistry, vol. 287, no. 12, pp. 9100–9111, 2012. View at Publisher · View at Google Scholar
  18. M. Fan, J. Rhee, J. St-Pierre et al., “Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK,” Genes and Development, vol. 18, no. 3, pp. 278–289, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. R. White, D. Morganstein, M. Christian, A. Seth, B. Herzog, and M. G. Parker, “Role of RIP140 in metabolic tissues: connections to disease,” FEBS Letters, vol. 582, no. 1, pp. 39–45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hallberg, D. L. Morganstein, E. Kiskinis et al., “A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA,” Molecular and Cellular Biology, vol. 28, no. 22, pp. 6785–6795, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. F. Chen and R. R. Behringer, “twist is required in head mesenchyme for cranial neural tube morphogenesis,” Genes and Development, vol. 9, no. 6, pp. 686–699, 1995. View at Google Scholar · View at Scopus
  22. D. Šošić, J. A. Richardson, K. Yu, D. M. Ornitz, and E. N. Olson, “Twist regulates cytokine gene expression through a negative feedback loop that represses NF-κB activity,” Cell, vol. 112, no. 2, pp. 169–180, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Bialek, B. Kern, X. Yang et al., “A twist code determines the onset of osteoblast differentiation,” Developmental Cell, vol. 6, no. 3, pp. 423–435, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Pan, M. Fujimoto, A. Lopes, and Y. X. Wang, “Twist-1 is a PPARδ-inducible, negative-feedback regulator of PGC-1α in brown fat metabolism,” Cell, vol. 137, no. 1, pp. 73–86, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Castet, A. Herledan, S. Bonnet, S. Jalaguier, J. M. Vanacker, and V. Cavaillès, “Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes,” Molecular Endocrinology, vol. 20, no. 5, pp. 1035–1047, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Uldry, W. Yang, J. St-Pierre, J. Lin, P. Seale, and B. M. Spiegelman, “Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation,” Cell Metabolism, vol. 3, no. 5, pp. 333–341, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Cao, K. W. Daniel, J. Robidoux et al., “p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene,” Molecular and Cellular Biology, vol. 24, no. 7, pp. 3057–3067, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. R. M. Barnes and A. B. Firulli, “A twist of insight—the role of twist-family bHLH factors in development,” International Journal of Developmental Biology, vol. 53, no. 7, pp. 909–924, 2009. View at Publisher · View at Google Scholar · View at Scopus