Research Article

The Impact of PPAR Genetic Variants on IBD Susceptibility and IBD Disease Course

Table 7

Impact of variant 12415557C>T on disease activity.

Category12415557C>T
GenotypeN (a)N (%) of SNP carriersOR (C.I.) OR (C.I.) (b)

FistulaHet plus hom7918 (22.8)1.02 (0.55–1.9)0.941.04 (0.56–1.95)0.89
No FistulaHet plus hom19445 (23.2)
Fistulahom621 (1.6)0.89 (0.07–9.2)1(c)0.89 (0.26–3.01)0.85
No Fistulahom1512 (1.3)

EIMHet plus hom11626 (22.4)1.10 (0.62–1.94)0.761.09 (0.61–1.93)0.78
No EIMHet plus hom15437 (24.0)
EIMhom922 (2.2)0.39 (0.03–4.31)0.580.65 (0.19–2.2)0.49
No EIMhom1181 (0.8)

Nonactive UCHet plus hom11428 (24.6)0.77 (0.24–2.49)0.780.89 (0.27–2.99)0.86
active UCHet plus hom204 (20.0)
Nonactive UChom871 (1.1)5.30 (0.32–90–42)0.33.28 (0.74–14.49)0.12
active UChom171 (5.9)

Quiescent CDHet plus hom9121 (23.1)1.16 (0.45–2.97)0.761.22 (0.47–3.17)0.68
Acute CDHet plus hom3125.8 (31)
Quiescent CDhom711 (1.4)NA1(c)NA1
Acute CDhom230 (0)

N: absolute number; OR: odds ratio; CI: confidence interval; het: heterozygous; hom: homozygous; NA: not applicable; (a)absolute number of subjects included into the respective analysis; (b)OR and value adjusted for age and sex; (c) value calculated with Fisher’s exact test (otherwise Chi-Square test was used).