Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

<table>The role of PPAR<i>γ</i> in the pathogenesis of fibrosis. PTEN induction by PPAR<i>γ</i> inhibits the PI3K/Akt pathway downregulating transcription factor Zf9, an inducer of TGF<i>β</i>. Resulting decrease of TGF<i>β</i> signaling leads to a decrease of collagen production. UPS regulates all these pathways (not shown).</table>

PPAR Research

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Figure 6

Figure 6: Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer 