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PPAR Research
Volume 2012 (2012), Article ID 640769, 6 pages
Review Article

Peroxisome Proliferator-Activator Receptor : A Link between Macrophage CD36 and Inflammation in Malaria Infection

W. M. Keck Center for Collaborative Neuroscience, Rutgers, the State University of New Jersey, Nelson Labs D-251, 604 Allison Road, Piscataway, NJ 08854, USA

Received 27 September 2011; Accepted 19 October 2011

Academic Editor: Dunne Fong

Copyright © 2012 Yi Ren. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Severe malaria infection caused by Plasmodium falciparum is a global life-threatening disease and a leading cause of death worldwide. Intensive investigations have demonstrated that macrophages play crucial roles in control of inflammatory and immune responses and clearance of Plasmodium-falciparum-parasitized erythrocytes (PE). This paper focuses on how macrophage CD36 recognizes and internalizes PE and participates the inflammatory signaling in response to Plasmodium falciparum. In addition, recent advances in our current understanding of the biological actions of PPARγ on CD36 and malaria clearance from the hosts are highlighted.