PPAR Research / 2012 / Article / Fig 2

Review Article

PPAR 𝜸 and Oxidative Stress: Con( 𝜷 ) Catenating NRF2 and FOXO

Figure 2

Crosstalk of PPARγ with NRF2, Wnt/β-catenin, and FOXO signaling pathways in oxidative stress response. ROS and other reactive species activate NRF2 and PPARγ that are linked by a positive feedback loop that sustains their expression. Through a negative feedback PPARγ inhibits Wnt/β-catenin and induces cell block. Activation of FOXO in turn blocks Wnt/β-catenin (diverting β-catenin from proliferation to resistance and apoptosis) and PPARγ. Finally, the result of these interactions, survival or cell death, depends on the action of other signaling pathways and regulatory circuits.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.