PPAR Research / 2012 / Article / Tab 2

Review Article

PPAR 𝜸 and Oxidative Stress: Con( 𝜷 ) Catenating NRF2 and FOXO

Table 2

Main experimental data linking PPARγ to NRF2, Wnt/β-catenin, and FOXO pathways.

InteractionGeneTargetEffectTissue or cell typeType of evidenceReferences

NRF2-PPARγNRF2PPARγ↑ expressionLiver, lungIn vitro
In vivo
PPARγNRF2↑ expressionLung, hepatocytes, macrophages, vascular tissueIn vitro
In vivo
[73, 77, 80, 82]
Wnt/β-catenin-PPARγWnt/β-cateninPPARγexpressionPre-adipocytes, adipocytes, skeleton, hepatic stellate cells, neurons, cancer cellsIn vitro
In vivo
[6, 90, 117121]
PPARγWnt/β-catenintranscriptional activity
↑ proteasomal degradation
↑ cytoplasmic localization
Colon, small intestine, colon cancer cells, hepatocytes, myeloid and lymphoid leukemic cellsIn vitro
In vivo
AdipocytesIn vitro
In vivo
PPARγFOXO activityAdipocytesIn vitro[129]

↑ = increasing; = decreasing.

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