Solution Structures of PPARγ2/RXRα Complexes

Figure 4

Solution structure of PPARγ2/RXRα bound to Cyp4A1 PPRE. (a) Scattering profiles of PPARγ2ΔNTD/RXRαΔNTD/PPRE. Experimental data are shown as red dots. Green fit is computed from the solution structure of the complex. (b) Distance distribution function computed from the X-ray scattering pattern using the program GNOM. (c) Most typical molecular envelope of PPARγ2ΔNTD/RXRαΔNTD/PPRE generated by DAMMIF (beads model shown as a grey surface) together with the refined model by rigid body refinement using the program SASREF (fit to the experimental data with 𝜒𝑅=0.98). (d) Pseudoatomic solution structure of PPARγ2ΔNTD/RXRαΔNTD/Cyp4A1 PPRE shown in schematic cartoon representation together with the sequence of the DNA.

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