PPARs in Liver Diseases and Cancer: Epigenetic Regulation by MicroRNAs

Table 1

miRNAs potentially targeting PPARγ, PPARα and PPARβ/δ. Four different databases, that is, miRanda (http://www.microRNA.org/), PicTar (http://www.pictar.org/), TargetScanHuman (http://www.targetscan.org/) and MicroCosm Targets (http://www.ebi.ac.uk/enright-srv/microcosm/htdocs/targets) were scanned to find all predicted miRNAs that possibly regulate PPARγ, PPARα and PPARβ/δ expression by binding to specific seed sequences in the transcribed 3′UTR regions of different PPARs isoforms.

(a)  

PPARα
miRanda		TargetScan	MicroCosm targets	PicTar
miR-25	miR-7	miR-200	miR-892	miR-19
miR-28	miR-9	miR-203
miR-32	miR-10	miR-204
miR-92	miR-17	miR-211
miR-145	miR-18	miR-214
miR-155	miR-19	miR-219
miR-181	miR-20	miR-223
miR-200	miR-21	miR-291
miR-216	miR-22	miR-294
miR-217	miR-23	miR-295
miR-218	miR-24	miR-302
miR-224	miR-27	miR-338
miR-342	miR-34	miR-351
miR-363	miR-93	miR-372
miR-367	miR-101	miR-373
miR-374	miR-105	miR-427
miR-376	miR-106	miR-428
miR-421	miR-124	miR-429
miR-425	miR-125	miR-449
miR-429	miR-128	miR-506
miR-431	miR-138	miR-508
miR-491	miR-141	miR-518
miR-543	miR-142	miR-519
miR-590	miR-144	miR-520
miR-615	miR-150	miR-548
miR-708	miR-181	miR-590
miR-873	miR-182	miR-670
		miR-761
		miR-1378
		miR-1420
		miR-3619
		miR-4262
		miR-4319
		miR-4735
		miR-4782
		miR-5127

(b)  

PPARγ
miRanda		Target scan	MicroCosm targets	Pictar
miR-1	miR-328	miR-27	miR-27	miR-27
miR-9	miR-329	miR-128	miR-30	miR-128
miR-18	miR-338	miR-130	miR-33	miR-130
miR-24	miR-340	miR-301	miR-34	miR-301
miR-25	miR-361	miR-454	miR-128
miR-26	miR-362	miR-721	miR-130
miR-27	miR-363	miR-3666	miR-142
miR-32	miR-367	miR-4295	miR-144
miR-33	miR-370		miR-193
miR-34	miR-371		miR-301
miR-92	miR-376		miR-338
miR-96	miR-411		miR-409
miR-101	miR-421		miR-431
miR-122	miR-431		miR-449
miR-128	miR-448		miR-454
miR-130	miR-449		miR-513
miR-133	miR-454		miR-520
miR-137	miR-485		miR-526
miR-142	miR-488		miR-545
miR-144	miR-490		miR-548
miR-145	miR-505		miR-559
miR-148	miR-590		miR-574
miR-150	miR-613
miR-152	miR-653
miR-153	miR-758
miR-181	miR-1271
miR-182	miR-1297
miR-185
miR-194
miR-199
miR-204
miR-206
miR-211
miR-224
miR-301
miR-324

(c)  

PPARβ/δ
miRanda	Target scan	MicroCosm targets	Pictar
miR-19	miR-9	miR-17	none
miR-24	miR-17	miR-20
miR-129	miR-20	miR-24
miR-133	miR-29	miR-29
miR-138	miR-34	mi; R-33
miR-140	miR-93	miR-93
miR-149	miR-106	miR-106
miR-185	miR-129	miR-136
miR-196	miR-138	miR-138
miR-218	miR-148	miR-143
miR-223	miR-150	miR-149
miR-326	miR-214	miR-219
miR-330	miR-223	miR-220
miR-342	miR-427	miR-222
miR-487	miR-449	miR-302
miR-590	miR-518	miR-373
miR-599	miR-519	miR-378
miR-653	miR-761	miR-483
miR-874	miR-3619	miR-492
	miR-5127	miR-512
		miR-513
		miR-519
		miR-520
		miR-542
		miR-544
		miR-550
		miR-564
		miR-576
		miR-631
		miR-640
		miR-657
		miR-874
		miR-885
		miR-921