TY - JOUR A2 - Alexson, Stefan AU - Elias-Miró, M. AU - Jiménez-Castro, M. B. AU - Mendes-Braz, M. AU - Casillas-Ramírez, A. AU - Peralta, C. PY - 2012 DA - 2012/05/16 TI - The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury SP - 802384 VL - 2012 AB - Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects. SN - 1687-4757 UR - https://doi.org/10.1155/2012/802384 DO - 10.1155/2012/802384 JF - PPAR Research PB - Hindawi Publishing Corporation KW - ER -