Structural Features and Transcriptional Activity of Chicken PPARs (, , and )
Figure 4
(a) Alignment of amino acid residues of chicken, mouse, and human PPARβ/δ LBDs. LBD is located at the C-terminus of chicken (amino acid residues 243 to 441) and mammalian (245 to 443) PPARβ/δ proteins. Amino acid residues conserved between mouse and human but not in chicken are highlighted in orange (mammals) and green (chicken). The amino acid residues critical for bezafibrate-dependent response of PPARβ/δ are indicated by a purple box. Accession numbers are as follows: cPPARβ, AAF80480; mPPARδ, NP_035275; hPPARδ, NP_001165289. (b) Bezafibrate (Beza) and carbaprostacyclin (cPGI) responsiveness of point mutated chicken PPARβ(Val419Met), human PPARα(Val444Met), and PPARδ(Met417Val) as previously reported [1].