PPAR Research / 2013 / Article / Tab 5

Clinical Study

Dual PPAR α/γ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia

Table 5

Plasma concentrations of Apo-B-containing lipoprotein particles (mg/dL) in patients with various degrees of chronic renal insufficiency (mild; n = 7, moderate; , severe; ) and healthy reference subjects (n = 17) at start and end of treatment with 1 mg tesaglitazar o.d. Mean and standard deviation (in parenthesis).

At entryAfter 6 weeksAt entryAfter 6 weeks

Lp-BLp-B : C

Reference group 67 (12)58 (10)6 (2)5 (2)
Mild CRF66 (9)59 (13)6 (1)7 (2)
Moderate CRF85 (21)70 (22)9 (5)6 (2)
Severe CRF86 (17)70 (20)15 (12)8 (4)

Lp-B : E + Lp-B : C : ELp-A-II : B : C : D : E

Reference group13 (6)10 (4)20 (9)15 (8)
Mild CRF14 (5)15 (3)16 (6)9 (3)
Moderate CRF22 (7)14 (5)17 (6)17 (7)
Severe CRF24 (9)14 (10)16 (9)20 (10)