PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance
Figure 3
Renin expression in kidneys of mice carrying wildtype or mutated Pal3 sequence in a human renin transgene. (a) Kidney sections from mice with wildtype Pal3 stained for mouse and human renin. The human renin is expressed as expected together with the mouse renin in the JG cells (yellow arrows). (b) Kidney sections from mice with mutated Pal3 stained for mouse and human renin. The human renin is expressed again together with the mouse renin in the JG cells (yellow arrow), but there are also JG cells negative for human renin (white arrow) demonstrating that the human renin expression is diminished.
