Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats
Effect of pioglitazone administration on nitric oxide synthase (NOS) expression and activities in the left ventricle and brainstem of young SHRs. (a) Expression of NOS1 and NOS3 isoforms was normalized to the expression of GAPDH. Data are shown for the left ventricle and brainstem. Bars represent mean ± SEM, . *, PIO versus control. (b) The NOS activities were determined using conversion of radioactive 3H-Arginine to 3H-Citrulline. The specific activities are expressed in pmols of citrulline produced in one min and related to 1 mg of proteins. Data are presented as mean ± SEM, .