PPAR Research / 2013 / Article / Fig 7

Research Article

Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats

Figure 7

Effect of pioglitazone administration on Akt kinase and β-catenin in the left ventricle and brainstem of young SHRs. (a) Western blot records documenting Akt kinase, β-catenin and GAPDH protein levels, and levels of Akt kinase phosphorylated specifically at Ser473 (P-Akt) in protein fractions isolated from the tissues of the left ventricle. (b) Western blot records documenting Akt kinase, β-catenin and GAPDH protein levels, and P-Akt in brainstem. (c) Quantification of Akt kinase protein levels normalized to the GAPDH protein levels in left ventricle and brainstem. (d) Quantification of β-catenin protein levels normalized to the GAPDH protein levels in left ventricle and brainstem. Data were obtained from Western blot records and each bar represents mean ± SEM, of 7 tissue samples per group. * , PIO versus control.
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