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PPAR Research
Volume 2013, Article ID 575604, 10 pages
http://dx.doi.org/10.1155/2013/575604
Research Article

The Liver X Receptor in Correlation with Other Nuclear Receptors in Spontaneous and Recurrent Abortions

1Department of Obstetrics and Gynaecology, Campus Innenstadt, Ludwig-Maximilians-Universität München, 80337 Munich, Germany
2Department of Pediatrics, University Medical Center Groningen, University of Groningen, Ctr Liver Digest & Metab Dis, 9700 AB Groningen, The Netherlands
3Research Center, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität München, 80337 Munich, Germany

Received 30 November 2012; Revised 7 February 2013; Accepted 14 March 2013

Academic Editor: Thierry Fournier

Copyright © 2013 Julia Knabl et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Regan and R. Rai, “Epidemiology and the medical causes of miscarriage,” Bailliere's Best Practice and Research in Clinical Obstetrics and Gynaecology, vol. 14, no. 5, pp. 839–854, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Rai and L. Regan, “Recurrent miscarriage,” Lancet, vol. 368, no. 9535, pp. 601–611, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Szanto, V. Narkar, Q. Shen, I. P. Uray, P. J. A. Davies, and L. Nagy, “Retinoid X receptors: X-ploring their (patho)physiological functions,” Cell Death and Differentiation, vol. 11, no. 2, supplement, pp. S126–S143, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Pestka, B. Toth, C. kuhn et al., “Retinoid X receptor alpha and retinoids are key regulators in apoptosis of trophoblasts of patients with recurrent miscarriages,” Journal of Molecular Endocrinology, vol. 47, no. 2, pp. 145–156, 2011. View at Publisher · View at Google Scholar
  5. D. J. Mangelsdorf and R. M. Evans, “The RXR heterodimers and orphan receptors,” Cell, vol. 83, no. 6, pp. 841–850, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. P. J. Willy, K. Umesono, E. S. Ong, R. M. Evans, R. A. Heyman, and D. J. Mangelsdorf, “LXR, a nuclear receptor that defines a distinct retinoid response pathway,” Genes and Development, vol. 9, no. 9, pp. 1033–1045, 1995. View at Google Scholar · View at Scopus
  7. X. K. Zhang and M. Pfahl, “Hetero- and homodimeric receptors in thyroid hormone and vitamin A action,” Receptor, vol. 3, no. 3, pp. 183–191, 1993. View at Google Scholar · View at Scopus
  8. B. Toth, D. Hornung, C. Scholz, S. Djalali, K. Friese, and U. Jeschke, “Peroxisome proliferator-activated receptors: new players in the field of reproduction,” American Journal of Reproductive Immunology, vol. 58, no. 3, pp. 289–310, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Tarrade, K. Schoonjans, L. Pavan et al., “PPARgamma/RXRalpha heterodimers control human trophoblast invasion,” Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 10, pp. 5017–5024, 2001. View at Google Scholar
  10. T. Jakobsson, E. Treuter, J.-A. Gustafsson, and K. Steffensen, “Liver X receptor biology and pharmacology: new pathways, challenges and opportunities,” Trends in Pharmacological Sciences, vol. 33, no. 7, pp. 394–404, 2012. View at Google Scholar
  11. G. Marceau, D. H. Volle, D. Gallot et al., “Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development,” The Anatomical Record, vol. 283, no. 1, pp. 175–181, 2005. View at Google Scholar
  12. L. Pavan, A. Hermouet, V. Tsatsaris et al., “Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors,” Endocrinology, vol. 145, no. 10, pp. 4583–4591, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Bełtowski and A. Semczuk, “Liver X receptor (LXR) and the reproductive system—a potential novel target for therapeutic intervention,” Pharmacological Reports, vol. 62, no. 1, pp. 15–27, 2010. View at Google Scholar · View at Scopus
  14. T. Plösch, E. M. E. van Straten, and F. Kuipers, “Cholesterol transport by the placenta: placental liver X receptor activity as a modulator of fetal cholesterol metabolism?” Placenta, vol. 28, no. 7, pp. 604–610, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Schneider, “Oxygenation of the placental-fetal unit in humans,” Respiratory Physiology and Neurobiology, vol. 178, no. 1, pp. 51–58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Hustin, E. Jauniaux, and J. P. Schaaps, “Histological study of the materno-embryonic interface in spontaneous abortion,” Placenta, vol. 11, no. 6, pp. 477–486, 1990. View at Publisher · View at Google Scholar · View at Scopus
  17. E. Jauniaux, M. R. Johnson, D. Jurkovic, B. Ramsay, S. Campbell, and S. Meuris, “The role of relaxin in the development of the uteroplacental circulation in early pregnancy,” Obstetrics and Gynecology, vol. 84, no. 3, pp. 338–342, 1994. View at Google Scholar · View at Scopus
  18. E. Jauniaux, B. Gulbis, and G. J. Burton, “Physiological implications of the materno-fetal oxygen gradient in human early pregnancy,” Reproductive BioMedicine Online, vol. 7, no. 2, pp. 250–253, 2003. View at Google Scholar · View at Scopus
  19. J. Hempstock, E. Jauniaux, N. Greenwold, and G. J. Burton, “The contribution of placental oxidative stress to early pregnancy failure,” Human Pathology, vol. 34, no. 12, pp. 1265–1275, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Jauniaux, J. Hempstock, N. Greenwold, and G. J. Burton, “Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies,” American Journal of Pathology, vol. 162, no. 1, pp. 115–125, 2003. View at Google Scholar · View at Scopus
  21. B. Toth, T. Haufe, C. Scholz et al., “Placental interleukin-15 expression in recurrent miscarriage,” American Journal of Reproductive Immunology, vol. 64, no. 6, pp. 402–410, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Tarrade, R. Lai Kuen, A. Malassiné et al., “Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta,” Laboratory Investigation, vol. 81, no. 9, pp. 1199–1211, 2001. View at Google Scholar · View at Scopus
  23. B. Toth, M. Bastug, I. Mylonas et al., “Peroxisome proliferator-activated receptor-gamma in normal human pregnancy and miscarriage,” Acta Histochemica, vol. 111, no. 4, pp. 372–378, 2009. View at Google Scholar · View at Scopus
  24. T. Fournier, K. Handschuh, V. Tsatsaris, J. Guibourdenche, and D. Evain-Brion, “Role of nuclear receptors and their ligands in human trophoblast invasion,” Journal of Reproductive Immunology, vol. 77, no. 2, pp. 161–170, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Chiang, Y. Litingtung, E. Lee et al., “Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function,” Nature, vol. 383, no. 6599, pp. 407–413, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Jeong and A. P. McMahon, “Cholesterol modification of Hedgehog family proteins,” Journal of Clinical Investigation, vol. 110, no. 5, pp. 591–596, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Bjorkhem and S. Meaney, “Brain cholesterol: long secret life behind a barrier,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 5, pp. 806–815, 2004. View at Google Scholar