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PPAR Research
Volume 2013, Article ID 613864, 23 pages
http://dx.doi.org/10.1155/2013/613864
Review Article

Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors

1Centre de Recherche INSERM-UMR866 “Lipides, Nutrition, Cancer” Faculté de Médecine, Université de Bourgogne 7, Boulevard Jeanne d’Arc, 21079 Dijon Cedex, France
2Laboratoire CarMeN, UMR INSERM U1060/INRA 1235, Université Lyon 1, Faculté de Médecine Lyon Sud, 165 Chemin du Grand Revoyet, 69921 Oullins, France
3Department of Chemical Physiology, The Scripps Research Institute, MB-24, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Received 15 October 2012; Revised 14 January 2013; Accepted 29 January 2013

Academic Editor: Massimo Bionaz

Copyright © 2013 Stéphane Mandard and David Patsouris. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [54 citations]

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  • Tian-Biao Zhou, Gregor P. C. Drummen, Zong-Pei Jiang, Yao-Bin Long, and Yuan-Han Qin, “Association of peroxisome proliferator-activated receptors/retinoic acid receptors with renal diseases,” Journal of Receptors and Signal Transduction, pp. 1–4, 2013. View at Publisher · View at Google Scholar
  • R. Martin Roop, and Clayton C. Caswell, “Bacterial Persistence: Finding the “Sweet Spot”,” Cell Host & Microbe, vol. 14, no. 2, pp. 119–120, 2013. View at Publisher · View at Google Scholar
  • Valérie Nicolas-Frances, Ségolène Arnauld, Jacques Kaminski, Emiel ver LOREN. van Themaat, Marie-Claude Clemencet, Julie Chamouton, Anne Athias, Jacques Grober, Joseph Gresti, Pascal Degrace, Laurent Lagrost, Norbert Latruffe, and Stéphane Mandard, “Disturbances in cholesterol, bile acid and glucose metabolism in peroxisomal 3-ketoacylCoA thiolase B deficient mice fed diets containing high or low saturated fat contents,” Biochimie, 2013. View at Publisher · View at Google Scholar
  • Louise Mackenzie, and Lisa Lione, “Harnessing the benefits of PPARβ/δ agonists,” Life Sciences, 2013. View at Publisher · View at Google Scholar
  • Jan M. Keppel Hesselink, David J. Kopsky, and Renger F. Witkamp, “Palmitoylethanolamide (PEA)-‘promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma,” PharmaNutrition, 2013. View at Publisher · View at Google Scholar
  • Valeria Gasperi, Isabella Savini, Maria Valeria Catani, Daniela Evangelista, and Luciana Avigliano, “Obesity-Associated Oxidative Stress: Strategies Finalized to Improve Redox State,” International Journal Of Molecular Sciences, vol. 14, no. 5, pp. 10497–10538, 2013. View at Publisher · View at Google Scholar
  • Koen Breyne, Steven K. Cool, Dieter Demon, Kristel Demeyere, Tom Vandenberghe, Peter Vandenabeele, Harald Carlsen, Wim Van den Broeck, Niek N. Sanders, and Evelyne Meyer, “Non-Classical ProIL-1beta Activation during Mammary Gland Infection Is Pathogen-Dependent but Caspase-1 Independent,” Plos One, vol. 9, no. 8, 2014. View at Publisher · View at Google Scholar
  • Daisuke Usuda, and Tsugiyasu Kanda, “Peroxisome proliferator-activated receptors for hypertension.,” World journal of cardiology, vol. 6, no. 8, pp. 744–54, 2014. View at Publisher · View at Google Scholar
  • Clorinda Lori, Alessandra Pasquo, Roberta Montanari, Davide Capelli, Valerio Consalvi, Roberta Chiaraluce, Laura Cervoni, Fulvio Loiodice, Antonio Laghezza, Massimiliano Aschi, Alessandra Giorgi, and Giorgio Pochetti, “Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy,” Acta Crystallographica Section D-Biological Crystallography, vol. 70, pp. 1965–1976, 2014. View at Publisher · View at Google Scholar
  • Jaap G. Neels, and Paul A. Grimaldi, “PHYSIOLOGICAL FUNCTIONS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR beta,” Physiological Reviews, vol. 94, no. 3, pp. 795–858, 2014. View at Publisher · View at Google Scholar
  • Alessio Papi, Sabrina De Carolis, Sara Bertoni, Gianluca Storci, Virginia Sceberras, Donatella Santini, Claudio Ceccarelli, Mario Taffurelli, Marina Orlandi, and Massimiliano Bonafé, “PPARγ and RXR Ligands Disrupt the Inflammatory Cross-talk in the Hypoxic Breast Cancer Stem Cells Niche,” Journal of Cellular Physiology, vol. 229, no. 11, pp. 1595–1606, 2014. View at Publisher · View at Google Scholar
  • Khuram Shahzad, Massimo Bionaz, Erminio Trevisi, Giuseppe Bertoni, Sandra L. Rodriguez-Zas, and Juan J. Loor, “Integrative Analyses of Hepatic Differentially Expressed Genes and Blood Biomarkers during the Peripartal Period between Dairy Cows Overfed or Restricted-Fed Energy Prepartum,” Plos One, vol. 9, no. 6, 2014. View at Publisher · View at Google Scholar
  • M. Jawad Khan, Carolina B. Jacometo, Daniel E. Graugnard, Marcio N. Corrêa, Eduardo Schmitt, Felipe Cardoso, and Juan J. Loor, “Overfeeding dairy cattle during late-pregnancy alters hepatic pparα-regulated pathways including hepatokines: Impact on metabolism and peripheral insulin sensitivity,” Gene Regulation and Systems Biology, vol. 2014, no. 8, pp. 97–111, 2014. View at Publisher · View at Google Scholar
  • Yan Zhang, Lingqing Hu, Yan Cui, Zhigang Qi, Xiaoping Huang, Liyi Cai, Ting Zhang, Yongxiang Yin, Zhiyi Lu, and Jingying Xiang, “Roles of PPAR gamma/NF-kappa B Signaling Pathway in the Pathogenesis of Intrahepatic Cholestasis of Pregnancy,” Plos One, vol. 9, no. 1, 2014. View at Publisher · View at Google Scholar
  • Jingjing Meng, Yanhua Fan, Mingzhi Su, Congqin Chen, Tianshu Ren, Jinhui Wang, and Qingchun Zhao, “WLIP derived from Lasiosphaera fenzlii Reich exhibits anti-tumor activity and induces cell cycle arrest through PPAR-γ associated pathways,” International Immunopharmacology, 2014. View at Publisher · View at Google Scholar
  • Renger F. Witkamp, “The endocannabinoid system: A dynamic signalling system at the crossroads between metabolism and disease,” AAPS Advances in the Pharmaceutical Sciences Series, vol. 12, pp. 155–187, 2014. View at Publisher · View at Google Scholar
  • Arthur J. Chu, “Antagonism by bioactive polyphenols against inflammation: A systematic view,” Inflammation and Allergy - Drug Targets, vol. 13, no. 1, pp. 34–64, 2014. View at Publisher · View at Google Scholar
  • János Molnár, Tibor Nagy, Viktor Stéger, Gábor Tóth, Ferenc Marincs, and Endre Barta, “Genome sequencing and analysis of Mangalica, a fatty local pig of Hungary,” BMC Genomics, vol. 15, no. 1, pp. 761, 2014. View at Publisher · View at Google Scholar
  • Giuseppe Danilo Norata, Giuseppina Caligiuri, Triantafyllos Chavakis, Giuseppe Matarese, Mihai Gheorge Netea, Antonino Nicoletti, Luke A.J. O’Neill, and Federica M. Marelli-Berg, “The Cellular and Molecular Basis of Translational Immunometabolism,” Immunity, vol. 43, no. 3, pp. 421–434, 2015. View at Publisher · View at Google Scholar
  • Déciga-Campos Myrna, Ramírez-Marín Pamela Moncerrat, and López-Muñoz Francisco Javier, “Synergistic antinociceptive interaction between palmitoylethanolamide and tramadol in the mouse formalin test,” European Journal of Pharmacology, vol. 765, pp. 68–74, 2015. View at Publisher · View at Google Scholar
  • Renger Witkamp, “Fatty acids, endocannabinoids and inflammation,” European Journal of Pharmacology, 2015. View at Publisher · View at Google Scholar
  • Lancelot Marique, Maximin Senou, Julie Craps, Aurélie Delaigle, Elliott Van Regemorter, Alexis Wérion, Victoria Van Regemorter, Michel Mourad, Catherine Nyssen-Behets, Benoit Lengelé, Lelio Baldeschi, Antonella Boschi, Sonia Brichard, Chantal Daumerie, and Marie-Christine Many, “Oxidative Stress and Upregulation of Antioxidant Proteins, Including Adiponectin, in Extraocular Muscular Cells, Orbital Adipocytes, and Thyrocytes in Graves' Disease Associated with Orbitopathy,” Thyroid, pp. 150819072530003, 2015. View at Publisher · View at Google Scholar
  • Maria Thomas, Christine Bayha, Kathrin Klein, Simon Müller, Thomas S. Weiss, Matthias Schwab, and Ulrich M. Zanger, “The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes,” BMC Cancer, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Jeffrey M. Peters, Pei-Li Yao, and Frank J. Gonzalez, “Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention,” Current Pharmacology Reports, vol. 1, no. 2, pp. 121–128, 2015. View at Publisher · View at Google Scholar
  • M. Bionaz, J. Osorio, and J. J. Loor, “TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows: Nutrients, transcription factors, and techniques1,2,” Journal of Animal Science, vol. 93, no. 12, pp. 5531–5553, 2015. View at Publisher · View at Google Scholar
  • M. Bionaz, J. Osorio, and J. J. Loor, “TRIENNIAL LACTATION SYMPOSIUM: Nutrigenomics in dairy cows: Nutrients, transcription factors, and techniques,” Journal Of Animal Science, vol. 93, no. 12, pp. 5531–5553, 2015. View at Publisher · View at Google Scholar
  • Chengming Sun, Guili Zhang, Shuping Luan, Caifu Luan, Huiyuan Shao, Fei Dong, and Xuena Liu, “ Evodiamine inhibits the proliferation of leukemia cell line K562 by regulating peroxisome proliferators-activated receptor gamma (PPAR γ ) pathway ,” Journal of Receptors and Signal Transduction, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • Roberto Scirpo, Romina Fiorotto, Ambra Villani, Mariangela Amenduni, Carlo Spirli, and Mario Strazzabosco, “Stimulation of nuclear receptor peroxisome proliferator-activated receptor-gamma limits NF-kappa B-dependent inflammation in mouse cystic fibrosis bil,” Hepatology, vol. 62, no. 5, pp. 1551–1562, 2015. View at Publisher · View at Google Scholar
  • Anthony R. Richardson, Greg A. Somerville, and Abraham L. Sonenshein, “Regulating the intersection of metabolism and pathogenesis in gram-positive bacteria,” Microbiology Spectrum, vol. 3, no. 3, 2015. View at Publisher · View at Google Scholar
  • Alexis Werion, Virginie Joris, Michael Hepp, Lida Papasokrati, Lancelot Marique, Christine de Ville de Goyet, Victoria Van Regemorter, Michel Mourad, Benoit Lengelé, Chantal Daumerie, Etienne Marbaix, Sonia Brichard, Marie-Christine Many, and Julie Craps, “Pioglitazone, a PPARγ Agonist, Upregulates the Expression of Caveolin-1 and Catalase, Essential for Thyroid Cell Homeostasis: A Clue to the Pathogenesis of Hashimoto's Thyroiditis,” Thyroid, 2016. View at Publisher · View at Google Scholar
  • Tom Ashmore, Jayne Wright, Julian L. Griffin, Zsuzsanna Ament, James A. West, Elizabeth Stanley, Lee D. Roberts, and Andrew W. Nicholls, “PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling,” Free Radical Biology and Medicine, vol. 95, pp. 357–368, 2016. View at Publisher · View at Google Scholar
  • Zsuzsanna Ament, James A. West, Elizabeth Stanley, Tom Ashmore, Lee D. Roberts, Jayne Wright, Andrew W. Nicholls, and Julian L. Griffin, “PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling,” Free Radical Biology And Medicine, vol. 95, pp. 357–368, 2016. View at Publisher · View at Google Scholar
  • Juan Wang, Xiao-Xia Zhu, Lei Liu, Yu Xue, Xue Yang, and He-Jian Zou, “SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway,” Endocrine, 2016. View at Publisher · View at Google Scholar
  • Sefika Pinar Senol, Meryem Temiz, Demet Sinem Guden, Pelin Cecen, Ayse Nihal Sari, Seyhan Sahan-Firat, John R. Falck, Rambabu Dakarapu, Kafait U. Malik, and Bahar Tunctan, “Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock,” Inflammation Research, 2016. View at Publisher · View at Google Scholar
  • Meimei Chen, Fafu Yang, Xuemei Yang, Xinmei Lai, and Yuxing Gao, “Systematic Understanding of Mechanisms of a Chinese Herbal Formula in Treatment of Metabolic Syndrome by an Integrated Pharmacology Approach,” International Journal of Molecular Sciences, vol. 17, no. 12, pp. 2114, 2016. View at Publisher · View at Google Scholar
  • D. Alemán-González-Duhart, F. Tamay-Cach, S. Álvarez-Almazán, and J. E. Mendieta-Wejebe, “Current Advances in the Biochemical and Physiological Aspects of the Treatment of Type 2 Diabetes Mellitus with Thiazolidinediones,” PPAR Research, vol. 2016, pp. 1–10, 2016. View at Publisher · View at Google Scholar
  • John R. KoetheComprehensive Physiology, pp. 1339–1357, 2017. View at Publisher · View at Google Scholar
  • Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Yusuke Koga, Takashi Nakamura, Meilei Harima, and Kenichi Watanabe, “Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus,” The International Journal of Biochemistry & Cell Biology, 2017. View at Publisher · View at Google Scholar
  • Wenjing Luo, Qinyu Xu, Qi Wang, Huimin Wu, and Jing Hua, “Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease,” Scientific Reports, vol. 7, pp. 44612, 2017. View at Publisher · View at Google Scholar
  • Maria Petrosino, Laura Lori, Alessandra Pasquo, Clorinda Lori, Valerio Consalvi, Velia Minicozzi, Silvia Morante, Antonio Laghezza, Alessandra Giorgi, Davide Capelli, and Roberta Chiaraluce, “Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes,” International Journal of Molecular Sciences, vol. 18, no. 2, pp. 361, 2017. View at Publisher · View at Google Scholar
  • María Antón, Alicia Rodríguez-González, Inmaculada Concepción Rodríguez-Rojo, Antoni Pastor, Ángeles Correas, Antonia Serrano, Antonio Ballesta, Francisco Alén, Raquel Gómez de Heras, Rafael de la Torre, Fernando Rodríguez de Fonseca, and Laura Orio, “Increased plasma oleoylethanolamide and palmitoleoylethanolamide levels correlate with inflammatory changes in alcohol binge drinkers: the case of HMGB1 in women,” Addiction Biology, 2017. View at Publisher · View at Google Scholar
  • John R. Koethe, Wyatt McDonnell, Arion Kennedy, Chike O. Abana, Mark Pilkinton, Ian Setliff, Ivelin Georgiev, Louise Barnett, Cindy C. Hager, Rita Smith, Spyros A. Kalams, Alyssa Hasty, and Simon Mallal, “Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons,” JAIDS Journal of Acquired Immune Deficiency Syndromes, pp. 1, 2017. View at Publisher · View at Google Scholar
  • Francisco Pérez-Vizcaíno, Marta Toral, Miguel Romero, Juan Duarte, and Rosario Jiménez, “Antihypertensive effects of peroxisome proliferator-activated receptor-β/δ activation,” American Journal of Physiology - Heart and Circulatory Physiology, vol. 312, no. 2, pp. H189–H200, 2017. View at Publisher · View at Google Scholar
  • Fernanda Rosa, Johan S. Osorio, Erminio Trevisi, Francisco Yanqui-Rivera, Charles T. Estill, and Massimo Bionaz, “2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis,” PPAR Research, vol. 2017, pp. 1–22, 2017. View at Publisher · View at Google Scholar
  • Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, and Daniele Fanale, “Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway,” PPAR Research, vol. 2017, pp. 1–15, 2017. View at Publisher · View at Google Scholar
  • B.M. Socha, P. Łada, A.A. Szczepańska, M. Łupicka, and A.J. Korzekwa, “The influence of experimentally induced endometritis on the PPAR expression profile in the bovine endometrium,” Theriogenology, 2018. View at Publisher · View at Google Scholar
  • Kassem Bourgi, Celestine Wanjalla, and John R. Koethe, “Inflammation and Metabolic Complications in HIV,” Current HIV/AIDS Reports, 2018. View at Publisher · View at Google Scholar
  • Jiapeng Chen, Alexandra Montagner, Nguan Tan, and Walter Wahli, “Insights into the Role of PPARβ/δ in NAFLD,” International Journal of Molecular Sciences, vol. 19, no. 7, pp. 1893, 2018. View at Publisher · View at Google Scholar
  • Xiaofang Li, Yan'e Gao, Pei Yang, Kunzheng Wang, Yue Li, and Run Tian, “Identification and validation of the role of matrix metalloproteinase-1 in cervical cancer,” International Journal of Oncology, vol. 52, no. 4, pp. 1198–1208, 2018. View at Publisher · View at Google Scholar
  • Daniel Busch, Amar Kapoor, Pia Rademann, Frank Hildebrand, Soheyl Bahrami, Christoph Thiemermann, and Marcin F Osuchowski, “Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation,” Innate Immunity, pp. 175342591877174, 2018. View at Publisher · View at Google Scholar
  • Nana Ma, Guangjun Chang, Jie Huang, Yan Wang, Qianyun Gao, Xiaoye Cheng, Jing Liu, and Xiangzhen Shen, “ cis -9, trans -11-Conjugated Linoleic Acid Exerts an Anti-inflammatory Effect in Bovine Mammary Epithelial Cells after Escherichia coli Stimulation through NF-κB Signaling Pathway ,” Journal of Agricultural and Food Chemistry, 2018. View at Publisher · View at Google Scholar
  • D. Dipasquale, L. Basiricò, P. Morera, R. Primi, A. Tröscher, and U. Bernabucci, “Anti-inflammatory effects of conjugated linoleic acid isomers and essential fatty acids in bovine mammary epithelial cells,” animal, vol. 12, no. 10, pp. 2108–2114, 2018. View at Publisher · View at Google Scholar
  • Luming Wei, Yuanhan Qin, Ling Jiang, Xueyun Yu, and Zhiyang Xi, “PPARγ and mitophagy are involved in hypoxia/reoxygenation-induced renal tubular epithelial cells injury,” Journal of Receptors and Signal Transduction, pp. 1–8, 2019. View at Publisher · View at Google Scholar
  • Li Bai, Yu Chen, Zhong-Ping Duan, and Su-Jun Zheng, “A new perspective on acute-on-chronic liver failure: Liver fibrosis and injury resistance,” World Chinese Journal of Digestology, vol. 27, no. 3, pp. 139–145, 2019. View at Publisher · View at Google Scholar