Specie Tissue Expression PPARα (NR1C1) Liver ++ [237 ] WAT N.D. Cow/cattle GI tract N.D. Brain N.D. Spleen/thymus N.D. Liver ++ [23 ] Chicken WAT + [82 ] Brain ++ [82 ] Spleen + [82 ] Liver +++ [20 , 61 , 118 , 162 , 175 ] Primary hepatocytes ± to +++ [61 , 134 ] HepG2 hepatoma cells + [54 ] HepaRG hepatoma cells ++ [134 ] Human WAT + [20 , 118 , 238 ] Isolated adipocytes ± [20 ] GI tract ++ [20 , 118 , 175 , 239 ] Brain + [118 , 175 , 240 ] Monocytes + [241 , 242 ] Dendritic cells ++ [241 , 242 ] Kidney ++ [20 , 118 ] Heart +++ [118 ] Pig Liver ± [243 ] WAT + [243 ] Liver +++ [61 , 83 , 244 –247 ] Hepatocytes ++ [61 ] GI tract ++
Nursa
[175 ] Mouse/rat Brain +
Nursa
Spleen/thymus − [83 ] Macrophages (BMDM) − [244 ] FAO hepatoma cells ++ [54 ] WAT + [62 , 248 ] PPAR
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(NR1C2) Liver N.D. WAT N.D. Cow/cattle GI tract N.D. Brain N.D. Spleen/thymus N.D. Liver N.D. WAT N.D. Chicken GI tract N.D. Brain N.D. Spleen/thymus N.D. Liver ± [20 ] HepG2 hepatoma cells ++ [54 ] WAT ± [20 ] Isolated adipocytes ± [20 ] Large intestine +++ [20 ] Small intestine + [20 ] Human Colon mucosae (adult) ++ [239 ] Brain N.D. Monocytes ++ [241 ] Macrophages +++ [249 ] Dendritic cells + [241 ] Kidney + [20 ] Skeletal muscle ± [20 ] Liver + [250 ] Pig WAT ++ [250 ] Stomach ++ [250 ] Brain ++ [250 ] Liver ± [251 ] Rabbit GI tract + [251 ] Brain ++ [251 ] Spleen/thymus ± [251 ] Liver + to ++
Nursa
[50 , 83 , 246 , 247 ] FAO hepatoma cells ++ [54 ] WAT +
Nursa
[50 ] Mouse/rat GI tract +++
Nursa
[50 , 175 ] Brain +++
Nursa
[50 , 83 , 193 , 252 ] Macrophages (BMDM) ++ [244 ] Colon ++ [83 ] PPARγ (NR1C3) Liver − [253 ] WAT +++ [253 , 254 ] Cow/cattle Spleen/thymus ++ [253 ] Small intestine ± [253 ] Mammary gland [235 ] Liver − [82 ] Chicken Spleen/thymus + [82 ] Brain + [255 ] WAT +++ [255 ] Liver + [20 , 256 , 257 ] HepG2 hepatoma cells + [54 ] HepaRG cells ± [134 ] Primary hepatocytes ± [134 ] WAT +++ [20 , 54 , 256 , 257 ] Human Isolated adipocytes +++ [20 ] Simpson-Golabi-Behmel Syndrome (SGBS) adipocytes +++ [84 ] Large intestine +++ [20 ] Small intestine ± [20 ] Brain N.D. Monocytes +++ [241 ] Dendritic cells +++ [241 ] Kidney + [20 ] Skeletal muscle ± [20 ] Pig Liver − [243 ] WAT ++ [243 ] Liver − to + [251 , 258 ] WAT +++ [258 ] Rabbit GI tract +++ [251 ] Brain − [251 ] Spleen/thymus ++ [251 ] Liver + to – [Nursa] [83 , 246 , 247 ] Hepatocytes + [259 ] FAO hepatoma cells − [54 ] WAT +++ [Nursa] [83 , 256 , 260 ] Mouse/rat 3T3-L1 adipocytes +++ [84 ] GI tract + [Nursa] [83 ] Brain + [Nursa] [83 , 261 , 262 ] Spleen/thymus ++ [83 ] Macrophages (BMDM) +++ [244 ]
