Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats

Figure 3

Caspase 3 immunohistochemical staining of apoptosis: immunohistochemical staining of Caspase 3 in liver tissues (PAP ×200) of (a) control animals showed negative (−) caspase 3 stain. (b) Highly positive (++++) for caspase 3 as in EE/CPZ group or fenofibrate plus GW6471 group. (c) Mild caspase 3 positivity (+) as in fenofibrate, bezafibrate, gemfibrozil, and UDCA groups. (d) Moderate cytoplasmic caspase 3 positivity (+++) as in bezafibrate plus GW6471. (e) Moderate positivity (++) in the cytoplasmic (granular) stain for caspase 3 as in gemfibrozil plus GW6471 group.

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