Research Article
Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs
Table 1
Drug binding affinity constants for human L-FABP and PPAR LBDs determined by fluorometric displacement assays.
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nd: no binding detected. An accurate measure of the could not be determined due to the combination of a low binding affinity of the receptor and the poor solubility of the drug. nt: not tested. *The logP and values for the compounds were calculated using the ACD Labs software. Determined by cis-parinaric acid displacement assay with L-FABP. |