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PPAR Research
Volume 2013, Article ID 980471, 8 pages
http://dx.doi.org/10.1155/2013/980471
Research Article

Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study

1Department of Preventive Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan
2Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
3Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
4Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan
5Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan
6Department of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4
7Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
8Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
9Division of Epidemiology, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
10Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
11Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
12Department of Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan
13Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan

Received 11 June 2013; Revised 28 August 2013; Accepted 9 September 2013

Academic Editor: Constantinos Giaginis

Copyright © 2013 Asahi Hishida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35–69 years, selected from J-MICC Study participants; genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3–5 (defined as eGFR < 60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04–1.53) and 1.31 (95%CI 0.83–2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.