Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse
Figure 1
Body weight of male WT and Wfs1 mutant mice. At the age of 16 months, Wfs1 KO (red circles) had lower body weight than WT (black circles) or heterozygous HZ (green circles) mice (; ). Growth rate of Wfs1 KO mice was inhibited since 8th to 9th week of age, while the body weight of WT and HZ continued to increase (; ). Chronic administration of VPA for 3 months (300 mg/kg/day, i.p. solid symbols) had no effect on growth rate regardless of genotype (; ). Data is presented as mean ± SEM ().
