The Antifibrosis Effects of Peroxisome Proliferator-Activated Receptor δ on Rat Corneal Wound Healing after Excimer Laser Keratectomy

Figure 1

Subconjunctival injection of GW501516, a PPARδ agonist, delayed reepithelialization during corneal wound healing in rats, which could be reversed by GSK3787, a PPARδ antagonist. (a) Representative photographs of rats’ ocular surfaces during the evaluation of corneal epithelial wound healing. Green areas represent fluorescein-stained areas of corneal epithelial defects. (b) The percentage rates of the remaining corneal epithelial defect area (% of each initial defect area) are shown at 24 and 48 h after surgery. The ranges of the -axis differ in each graph. Data are presented as the mean ± SD (), and significant differences were statistically assessed by ANOVA. , , versus GW501516 group.

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