TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation
Dietary capsaicin upregulates PPAR-δ and UCP2 protein expression and decreases iNOS production in mice on long-term high-salt diet through TRPV1 activation. Immunoblottings of PPAR- (a), UCP2 (b), and iNOS (c) were performed in the left ventricular in WT and TRPV1−/− from various groups. Data are means ± SEM from 3 separate experiments. , versus NS, # versus HS.