TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation

Figure 4

Dietary capsaicin upregulates PPAR-δ and UCP2 protein expression and decreases iNOS production in mice on long-term high-salt diet through TRPV1 activation. Immunoblottings of PPAR-𝛿 (a), UCP2 (b), and iNOS (c) were performed in the left ventricular in WT and TRPV1^−/− from various groups. Data are means ± SEM from 3 separate experiments. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus NS, ^#𝑃<0.05 versus HS.

(a)

(b)

(c)