Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver

Table 1

Effect of fenofibrate (FEN) and pioglitazone (PIO) on histological findings in cyclophosphamide (CP)-treated rats liver.

	Degeneration and necrosis	Fatty changes	Inflammatory cell infiltration
Control	−	−	−
FEN	+	−	−
PIO	−	−	−
CP	+++	++	+++
CP/FEN	+++	+++	+++
CP/PIO	+	−	−

From each animal, 5 sections were examined and scored according to the following criteria: (−) = absent, (+) = mild, (++) = moderate, and (+++) = severe changes.