Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver

Table 2

Effect of fenofibrate (FEN) and pioglitazone (PIO) on change (Δ) of total body weight (wt), liver/body wt ratio, and liver function parameters in cyclophosphamide (CP)-treated rats.

	Control	FEN	PIO	CP	CP/FEN	CP/PIO
ΔBody wt (%)	100 ± 9	99 ± 9	99 ± 7	79 ± 5^a	82 ± 4^a	94 ± 6^b,c
Liver/wt ratio	198.3 ± 25.8	192.4 ± 31.4	181.9 ± 29.1	314.8 ± 40.2^a	329.2 ± 21.6^a	201.8 ± 32.4^b,c
Albumin (g/dL)	3.2 ± 0.7	2.9 ± 0.3	3.5 ± 0.2	1.9 ± 0.4^a	1.7 ± 0.8^a	2.9 ± 0.7^b,c
Total bilirubin (mg/dL)	0.18 ± 0.03	0.22 ± 0.08	0.19 ± 0.02	0.39 ± 0.09^a	0.36 ± 0.04^a	0.25 ± 0.06^b,c
ALT (U/dL)	39.9 ± 3.4	45.1 ± 8.8	35.1 ± 11.8	71.8 ± 14.2^a	68.3 ± 9.1^a	55.3 ± 7.8^b
AST (U/dL)	99.1 ± 14.9	110.1 ± 12.3	95.6 ± 12.5	192.8 ± 16.3^a	181.9 ± 11.3^a	144.3 ± 8.3^b
ALP (U/L)	130.5 ± 16.1	140.9 ± 18.6	122.7 ± 17.8	292.3 ± 26.2^a	295.2 ± 21.7^a	184.7 ± 18.9^b
LDH (U/L)	782.2 ± 36.2	820.2 ± 38.4	799.2 ± 42.3	1452.4 ± 76.8^a	1445.1 ± 21.7^a	1142.9 ± 88.3^b

Liver/wt is ratio of weight of liver divided by total body wt * 1000 ratio. ALT: alanine transaminase, AST: aspartate transaminase, ALP: alkaline phosphatase, and LDH: lactate dehydrogenase. Values are representation of 8 observations as means ± SEM. Results are considered significantly different when 𝑃<0.05. ^aSignificant difference compared to control, ^bsignificant difference compared to CP group, ^cno significant difference compared to control.