The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population

Table 1

Demographic and clinical characteristics of the study subjects in the sepsis and control groups.

Characteristics	Cases (𝑛=308)	Controls (𝑛=345)	𝑃 value
	𝑛 (%)	𝑛 (%)
Age (years)	62.36±17.17	54.90±15.73	0.412
Male/female, 𝑛	217/91	222/123	0.097
Organ dysfunction
One, 𝑛 (%)	48 (15.6)	N.A.
Two, 𝑛 (%)	89 (28.9)	N.A.
Three or more, 𝑛 (%)	141 (45.8)	N.A.
Sepsis status
Sepsis, 𝑛 (%)	30 (9.7)	N.A.
Septic shock, 𝑛 (%)	97 (31.5)	N.A.
Severe sepsis, 𝑛 (%)	181 (58.8)	N.A.
Source of infection, 𝑛 (%)
Respiratory tract infection	240 (77.9)	N.A.
Primary bloodstream infection	85 (27.6)	N.A.
Wound infection	38 (12.3)	N.A.
Abdominal infection	109 (35.4)	N.A.
Urinary tract infection	13 (4.2)	N.A.
Catheter-associated infection	25 (8.1)	N.A.
Other	19 (6.2)	N.A.
Pathogens, 𝑛 (%) (positive blood cultures)
Gram-negative	104 (33.8)	N.A.
Gram-positive	51 (16.5)	N.A.
Mixed Gram-negative and positive	108 (35.1)	N.A.
Fungus	32 (10.4)	N.A.
Negative blood cultures	13 (4.2)	N.A.
APACHE-II score	23.1±4.7	N.A.
28-day mortality, 𝑛 (%)	36.5	N.A.

N.A.: not Applicable; APACHE II: Acute Physiology and Chronic Health Evaluation II.